Duration
21h Th, 27h Pr
Number of credits
| Bachelor in bioengineering | 4 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
After reviewing the concepts of chemical bonding, the nomenclature of organic molecules will be presented. Stereochemistry will then address how organic molecules differ according to their configuration in space. The remaining chapters of the course focus individually on a family of organic compounds by reviewing their nomenclature, describing their reactivity, the factors that influence it, and illustrating some of their properties. In parallel, the foundations of certain spectroscopic techniques used for the structural analysis of molecules will also be detailed and applied to simple cases.
The theoretical course is structured as follows:
Chapter 1 - Introduction
Chapter 2 - Review of the electronic structure of molecules
Chapter 3 - Nomenclature of organic molecules
Chapter 4 - Conformers, isomers, stereoisomers
Chapter 5 - Alkenes
Chapter 6 - Alkanes
Chapter 7 - Mass spectrometry
Chapter 8 - Halogenoalkanes
Chapter 9 - Alcohols
Chapter 10 - Delocalized electrons and UV-Vis spectrometry
Chapter 11 - Carbonyls
Chapter 12 - Infrared spectrometry
Chapter 13 - Aromatic compounds
Chapter 14 - NMR
Tutorial sessions apply the concepts covered in the theoretical course through exercise sessions organized as follows:
TUT1: Nomenclature
TUT2: Stereochemistry
TUT3: Reactivity of alkenes, alkanes & halogenoalkanes
TUT4: Reactivity of alcohols, carbonyl compounds & structure determination
TUT5: Reactivity of benzenes, aromaticity & concept of acidity
A lecture hall session is generally organized at the end of the semester to allow the resolution of comprehensive synthesis and retrosynthesis exercises.
Laboratory sessions provide an opportunity to illustrate in practice some of the reactions or concepts covered during the course:
LAB1: Study of the stereochemistry of the electrophilic addition of dibromine to trans-stilbene
LAB2: Biosynthesis and distillation of ethanol & saponification reaction
LAB3: Methods for identifying an unknown carbonyl compound
Learning outcomes of the learning unit
At the end of the course, the student will be able to:
*Master the basic nomenclature used in organic chemistry
*Distinguish, characterize, and name the different types of isomerism and be able to apply these concepts in the context of chemical reactions
*Understand and apply the major concepts governing the behavior of organic molecules (electrophile/nucleophile, steric hindrance, inductive effect, acidity, electron delocalization, aromaticity)
*Know and apply to concrete examples the major types of reactions encountered in organic chemistry (additions, substitutions, eliminations, oxidations, reductions, etc.)
*For the main functional groups, understand and interpret their reaction mechanisms and the factors influencing them
*Understand the operation of the principal spectral analysis methods (IR, UV-Vis, NMR spectroscopy and mass spectrometry) and their potential applications for bioengineers
*Be able to apply all the above-mentioned concepts to solving simple synthesis or retrosynthesis problems
*Acquire basic practical experience in performing experiments in an organic chemistry laboratory
Prerequisite knowledge and skills
General chemistry : from atom to molecule - Bachelor in bioengineering, 1st year (CHIM9268 -1), particularly the section on the atomistic and concepts related to chemical bonds.
Planned learning activities and teaching methods
Ex cathedra theoretical lectures delivered in 10 sessions of 2 hours.
Tutorial sessions (TUT), 5 sessions of 3 hours.
Laboratory practical sessions (LAB) in the laboratory, 3 sessions of 4 hours.
Synthesis and spectral analysis exercises, 1 session of 1 hour + tutoring sessions on appointments with the teaching assistant.
But also: supplementary exercises, nomenclature quizzes, and solutions to selected examination questions. All materials are available on e-campus throughout the semester.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Course materials and recommended or required readings
Platform(s) used for course materials:
- eCampus
Further information:
Theoretical course notes available on eCampus
Exercises notes available on eCampus
Practical work (lab protocoles) notes available on eCampus
Reference Manual:
" Organic Chemistry " P. Bruice, 2nd Edition, Pearson
Further Reading:
" Organic chemistry: the principles " J. Mc Murry and E. Simanek (Dunod)
"Treaty of Organic Chemistry «, P. Vollhardt and N. Schore, de Boeck
" General Chemistry " J. Hill, A. Petrucci, T. McCreary, S. Perry, Prentice Hall
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
- Remote
written exam ( multiple-choice questionnaire, open-ended questions ) AND oral exam
Written work / report
Further information:
All examination sessions considered (first session: January, second session: August) :
Written exam
Assignment : laboratory report to be submitted after each lab activities
Written examination lasting 3 hours (first session: January, second session: August).
The examination includes both theoretical concepts and practical exercises. A periodic table and unannotated reaction tables are provided during the examination. Molecular models may be brought to the examination, and students are encouraged to use them throughout the examination.
Practical component (laboratories): grade obtained from the laboratory entry test (5/20) and the laboratory report assessment (15/20). The overall laboratory grade counts for 20% of the final course grade. Attendance at laboratory sessions is mandatory. In the event of an unjustified absence, the student will not be authorized to take the examination.
Work placement(s)
Organisational remarks and main changes to the course
Supervising Team:
Prof. Marie-Laure Fauconnier, course instructor
Florian Martini, teaching assistant, BAC2 coordinator
Dr. Manon Genva, associated professor
Adrien Francis, technician
Franck Michels, technician
Thomas Bertrand, technician
Contacts
Prof. Marie-Laure Fauconnier: marie-laure.fauconnier@uliege.be
Teaching Assistant: Florian Martini florian.martini@uliege.be
Laboratory of Natural Molecule Chemistry (general and organic chemistry), Gembloux Agro-Bio Tech Faculty, cloister building, chemistry department, first floor on the left.
Any questions regarding the course content are welcome before, after, or during theoretical lectures, tutorial sessions, and laboratory sessions.
Tutoring sessions may be arranged subject to scheduling an appointment with the teaching assistant during office hours.
Questions may also be asked via e-campus or by email.