Duration
20h Th, 25h Pr
Number of credits
| Bachelor in chemistry | 4 crédits |
Lecturer
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The course aims to give students a logical method of identifying unknown molecules based on a set of spectra. The course emphasizes the complementarity of physico-chemical methods, including mass spectrometry, infrared spectroscopy, UV-Visible spectroscopy and nuclear magnetic resonance. The methods are introduced successively, by means of examples whose resolution requires the cumulative contribution of the techniques introduced at this moment of the course. Mass spectrometry and associated methods (MS / MS) are essential methods widely used in the chemical industry and control laboratories. It requires a good knowledge of basic chemistry and reactivity in organic chemistry as well as the interpretation of isotopic distributions. Nuclear magnetic resonance is an important second part of the course. It comes in addition to the notions introduced in Organic Chemistry and Physical Chemistry. The use of 1 H and 13 C NMR as well as the basic notions of two-dimensional NMR (2D NMR) are amply illustrated. Examples also include organometallic compounds with non-zero spin central atoms. The course gives a large part to the resolution of exercises.
Learning outcomes of the learning unit
The objectives of the course are to gather the theoretical and experimental tools necessary to the determination of the structure of organic, organometallic and biological molecules and to describe the method of optimal use of spectroscopic information to determine an univocal structure, at least until connectivities.
Prerequisite knowledge and skills
General Organic Chemistry
General Physical Chemistry
Planned learning activities and teaching methods
Problem solving sessions of increasing complexity, in sync with the techniques gradually seen during, under the supervision of an assistant. These exercises prepare for a working method allowing for proper management of time and information. Access to spectral databases (ULgSpectra) and familiarization with measuring instruments will also be provided
Mode of delivery (face-to-face ; distance-learning)
Reference books More Spectroscopic Problems in Organic Chemistry (Spectroscopy in Chemical Education, Baker et al, Heyden, 1967) Organic Structure from Spectra (Sternell et Kalman, Wiley, 1987) Spectrometric Identification of Organic Compounds (Silverstein, Bassler et Morill, Wiley, Ed7, 2005)
Recommended or required readings
Reference books More Spectroscopic Problems in Organic Chemistry (Spectroscopy in Chemical Education, Baker et al, Heyden, 1967) Organic Structure from Spectra (Sternell et Kalman, Wiley, 1987) Spectrometric Identification of Organic Compounds (Silverstein, Bassler et Morill, Wiley, Ed7, 2005)
Assessment methods and criteria
Written exam. Knowlege and understanding of the theory and basic principle will be evaluated. the ability to apply the theory will be evaluated by the analysis of unknown compounds using multiple spectra.
Work placement(s)
Organizational remarks
Contacts
Pr. Christian Damblon
Institut de Chimie, Bât. B6, 4000 Liège 1, Sart Tilman
e-mail: c.damblon@ulg.ac.be
Prof. Loïc Quinton
Laboratory of Mass Spectrometry - Biological Chemistry
MolSys Research Unit
Allée du six Aout 11 - Quartier Agora
B4000 -Liège 1 - Belgium
Tel +32 4 366 3679
loic.quinton@uliege.be
Sophie Rappe, doctorante, Assistante
e-mail:sophie.rappe@ulg.ac.be
Adaptation of teaching commitments following the COVID-19 pandemic for the May-June 2020 session
Teaching methods implemented : distance-learning
Lectures are recorded on video and are available as PODCAST. The presentation slides are also available. The entire teaching staff remains available to answer questions by email.
Assessment subjects
The assesment topics will consist of that presented in lectures and in podcasts.
Assessment methods
The exam will consist of open questions of understanding of the theory and exercises of structural analysis. The exercises will consist in solving structures from spectra of the UlgSpectra database.
The assessment will be made by a written test carried out remotely ("online"). Students will receive the exam questionnaire by email (or e-Campus) according to the schedule defined in CELCAT. On the day of the exam, students will confirm by return e-mail to sophie.rappe@uliege.be that the exam questionnaire has been received. They will then have 2 hours to answer the exam questionnaire. Two options are possible; either the student responds on a blank sheet of paper in a handwritten manner, or he uses a word processor. Before the time runs out, students must send their response by e-mail (or by e-campus) to the teacher (sophie.rappe@uliege.be) either as a word file or as a photo file of the JPEG, TIFF or PDF type (photo of the exam copy taken with a mobile phone for example) of their handwritten response. The name of the course and the student number must imperatively be mentioned in the subject of the email. The teacher will confirm by return e-mail that the exam copy has been received.
A computer and a stable internet connection will be required to perform the exam in good conditions.
For students who have had problems sending answers by email, an oral exam will be organized by videoconference.
Contacts
Sophie Rappe : sophie.rappe@uliege.be
Loïc Quinton : loic.quinton@uliege.be
Christian Damblon : c.damblon@uliege.be
Adaptation of teaching commitments following the COVID-19 pandemic for the Aug-Sept 2020 session
Assessment subjects
Lectures are recorded on video and are available as PODCAST. The presentation slides are also available. The entire teaching staff remains available to answer questions on the forum on e-Campus.
The assessment topics will consist of that presented in lectures and in podcasts.
Assessment methods
The exam will consist of open questions of understanding of the theory and exercises of structural analysis. The exercises will consist in solving structures from spectra of the UlgSpectra database.
The assessment will consist of two separate written tests (Theory and Exercise) carried out remotely ("online"). Students will receive by e-mail (or by e-Campus) separate exam, theory and exercise questionnaires according to the schedule defined in CELCAT.
The theoretical part will be sent first and the students will have 30 min to answer it. Students will then have 15 minutes to send their response by email to c.damblon@uliege.be and Sophie.Rappe@uliege.be.
The exercise questionnaire will be made available 45 minutes after the theory. Students will then have 90 minutes to do the exercise and 15 minutes to email their response to c.damblon@uliege.be and Sophie.Rappe@uliege.be.
For the answers: two options are possible; either the student answers on a blank sheet of paper in a handwritten manner, or he uses a word processor. The student ID number must be written on each sheet which must be numbered (x / total number of pages). Before the time runs out, students must send their response by e-mail either as a Word file or as a photo file of the JPEG, TIFF or PDF type (photo of the exam copy taken with a mobile phone or a scanner, for example) of their handwritten response. The ID of the course and the student ID number must be mentioned in the subject line of the email. In order for teachers to confirm that the exam copy has been received, the student must request an acknowledgment when it is sent.
A computer and a stable internet connection will be required to perform the exam in good conditions.
For students who have had problems sending answers by email, an oral exam will be organized by videoconference.
Contacts
Sophie Rappe : sophie.rappe@uliege.be
Loïc Quinton : loic.quinton@uliege.be
Christian Damblon : c.damblon@uliege.be