Duration
38h Th, 28h Pr
Number of credits
| Master in bioengineering : chemistry and bio-industries (120 ECTS) | 7 crédits |
Lecturer
Frank Delvigne, Patrick Fickers, Philippe Jacques, Marc Ongena, Jean-Claude Twizere
Coordinator
Language(s) of instruction
English language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
This course focus on theoretical and practical aspects on technologies related to the production of compounds of biotechnological interest (biomass, proteins, metabolites) for agro-food, chemical and biopharmaceutical industries. The course details the different technologies of bioreactor culture, molecular techniques leading to the development of "cell factory" as well as cell-environment interactions.
Learning outcomes of the learning unit
At the end of this multidisciplinary module, students will be able to integrate the different aspects of the development, implementation, optimization and control of a process of production of a compound of interest in bioreactor. The course also includes dimensioning part (calculation of oxygen transfer capacity, dynamics of microbial growth and production of metabolites, ...) and on the construction of dynamic models of bioprocesses (resolution of first-order differential equations under MatLab).
Prerequisite knowledge and skills
BIOL2010-1 : Biologie cellulaire
BIOL2013-2 : Microbiologie générale - Patrim 1
BIOL2013-3 : Microbiologie générale - Partim 2
BIOL2015-3 : Biologie moléculaire
BIAA0003-1 : Génie industriel alimentaire et ingénierie agro-alimentaire - 1ère partie
CHIM9241-1 : techniques de séparation et de concentration
MATH2016-1 : mathématique générale et modélisation des systèmes dynamiques
Planned learning activities and teaching methods
- Bioreactor engineering (F. Delvigne, 12 h Th)
- Metabolic engineering (P. Fickers, P. Jacques, 12 h Th)
- Microbial interaction (M. Ongena, 12 h Th)
- Animal cell culture (JC Twizere , 12 h Th)
- Exercices (F. Delvigne, P. Fickers, P. Jacques, 12 h, )
- Lab (P. Fickers, P. Jacques, M. Ongena, F. Delvigne, 12 h)
- Numerical simulation (F. Delvigne, 12 h, exercices)
Beside ex-cathedra courses, this module includes practical lab work, exercises (simulation on MatLab), seminars (industrials, academics or research centers) and company visits Active. In this course, a pedagogical approach "learning by doing" will also be favored..
Mode of delivery (face-to-face ; distance-learning)
Lectures
Lab training
Exercices (numerical simulation using MatLab),
Seminars
Company visit
In this course, a pedagogical approach "learning by doing" will also be favored.
Recommended or required readings
Assessment methods and criteria
Report and oral presentation
Oral and writen exam
Work placement(s)
Organizational remarks
Contacts
Prof. Patrick Fickers
Microbial Processes and Interactions (MiPI)
Ph: 081 622 311 (direct), 081 622 305 (secretariat)
pfickers@ulg.ac.be
Adaptation of teaching commitments following the COVID-19 pandemic for the May-June 2020 session
Teaching methods implemented : distance-learning
The lessons and exercise sessions are given remotely via LifeSize using the course notes available on eCampus or sent directly to students (power point files) and according to the schedule included in CelCAT. Some sessions are recorded and the video files are also deposited on eCampus. Exercise resolutions related to modeling are available on a GitLab directory at the following address: https://gitlab.uliege.be/F.Delvigne/bioreactor-modelling-and-systems-biology.
Assessment subjects
The matter for the oral evaluation corresponds to the following parts:
- From the screening to the formulation of microbial products, the example of lipopeptides (Pr. Philippe Jacques)
- Bioreactor modeling and system biology (Pr. Frank Delvigne) + Conference "Mass spectrometry with single microbial cell" (Dr Christian Dusny)
- Microbial Interactions (Pr. Marc Ongena)
- Bioninformatics exercises (Pr. Philippe Jacques)
- Patent exercises (Pr. Philippe Jacques and F. Piron)
- Cell cultures exercises (Pr. Jean-Claude Twizere)
Assessment methods
Oral exam via LifeSize according to the schedule included in CelCAT. An order of passage and the precise modalities of the exam will be communicated in due time by e-mail via eCampus.
Three written works: bioinformatics work (P. Jacques) submitted for March 29, intellectual property work (P. Jacques) to be submitted by April 30 and article review to be sent by email before June 10, 2020 (JC Twizere).
Contacts
Marc Ongena (marc.ongena@uliege.be) , Frank Delvigne (f.delvigne@uliege.be), Jean-Claude Twizere (jean-claude.twizere@uliege.be), Philippe Jacques (Philippe.jacques@uliege.be).
Adaptation of teaching commitments following the COVID-19 pandemic for the Aug-Sept 2020 session
Assessment subjects
Assessment methods
Contacts
Items online
Interactome networks to understand genotype-phenotype relationships
The slides contain key slides to explain genotype - phenotype relationships, based on the understanding genotype-phenotype relationships. We will focus on protein-protein interactions technologies and give pratical examples.