Duration
40h Th, 10h SEM
Number of credits
| Bachelor in pharmacy | 5 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Systematic part 2 : drugs of the central nervous system, drugs of the peripheral nervous system, local anaesthetics, antihistaminics, drugs of the cardiovascular system, of the renal system and of the blood, drugs of the respiratory system, drugs of the gastrointestinal tract, of the metabolic and nutritional disorders, hormones, dermatological drugs, contrast products, miscelleanous.
Learning outcomes of the learning unit
Medicinal chemistry is a science devoted to the design, the synthesis and the understanding of the mode of action of drugs, and more specifically, those obtained by organic synthesis. This science tries to establish a link between the chemical structure of a drug and its biological activity.
The general aims of this course are the following : to familiarize the student with the active components of drugs, their chemical structures, their origin, their design, their evolution, the field of their therapeutic applications, their international nonproprietary names and several examples of trade marks. Some examples of synthesis are provided, the general physicochemical properties are reviewed. The systematic part is introduced by the presentation of the traditional and innovative steps in drug design, by the review of classical synthetic processes and by a summary of the I.U.P.A.C. nomenclature.
At the end of this training, the student must be able to:
- understand how drugs (small molecules) are designed (drug design), prepared (organic synthesis) and named (i.e. nomenclature of heterocyclic compounds);
- establish relationships between the chemical structure of the drugs and their biological and therapeutic action (structure-activity relationships), as well as the main physico-chemical properties (solubility, acido-basic character, stability, chirality, ...);
- know/recognize the main drugs on the Belgian market by their name (INN, trademark) and their chemical structure and to locate them in their pharmacological class (main therapeutic uses).
Prerequisite knowledge and skills
Appropriate knowledge of inorganic and organic chemistry, basic knowledge of physiology.
Planned learning activities and teaching methods
Seminars (10 h) : revision of selected theoretical aspects ; solubility, hydrophilicity and lipophilicity associated with drugs; acido-basic character of drugs; importance of the stereochemistry; quantitative structure-activity relationships; development steps; nomenclature; case studies of drug design.
Mode of delivery (face-to-face ; distance-learning)
The lessons (1 h 30) are usually given twice weekly during the second quadrimester.
Recommended or required readings
Written notes upgraded each year are distributed to the students.
Assessment methods and criteria
Written exam in may-june (first session).
Written exam in august-september (second session).
An oral rattrapage exam may be organized in June for students with a note > or = to 8/20 and < to 10/20.
Work placement(s)
Organizational remarks
Contacts
Professeur Bernard PIROTTE Laboratoire de Chimie Pharmaceutique Quartier Hôpital, 15, Avenue Hippocrate, B-4000 Liège C.H.U. - tour 4 - niveau + 5 (Bât. B36) tel : 04 366 43 65 - fax : 04 366 43 62 e-mail: B.Pirotte@uliege.be Secrétariat : Mme Annabelle HAMANDE (tel : 04 366 43 61)
Adaptation of teaching commitments following the COVID-19 pandemic for the May-June 2020 session
Teaching methods implemented : distance-learning
Distance learning through the provision of videos presenting the chapters of the course remaining to be addressed until the end of the term (ppt slides with voice recording).
The course notes and all the slides have been made available on the e-campus platform.
Assessment subjects
The evaluation will be focused on the material contained in the course notes. Additional information and specific points of attention are addressed by the video presentations.
The list of structures/DCI/registered trademarks to know or to recognize remains unchanged.
Assessment methods
The knowledge assessment will be done remotely via the e-campus platform in the form of a two-hour written examination (multiple choice/true-false/short answers).
An oral drafting examination (by videoconference) may be organized for students who have had real computer connection difficulties at the time of the test.
If circumstances allow, a remedial oral exam (by videoconference) may be organized for students who have obtained a written score > or = at 8/20 and < at 10/20.
Contacts
Bernard Pirotte (b.pirotte@uliege.be) 0476 30 55 14
Adaptation of teaching commitments following the COVID-19 pandemic for the Aug-Sept 2020 session
Assessment subjects
The evaluation will be focused on the material contained in the course notes. Additional information and specific points of attention are addressed by the video presentations.
The list of structures/DCI/registered trademarks to know or to recognize remains unchanged.
Assessment methods
The knowledge assessment will be done remotely via the e-campus platform in the form of a 150 minutes written examination (multiple choice/true-false/short answers).
Contacts
Bernard Pirotte (b.pirotte@uliege.be) 0476 30 55 14