Duration
20h Th, 5h SEM
Number of credits
| Master in chemistry (120 ECTS) | 3 crédits | |||
| Master in chemistry (60 ECTS) | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The course reviews the fundamental principles used in drug design. It tries to explain how were found, and how are still selected today, the new chemical entities developed as new therapeutic agents. The course tries to establish a link between the chemical structure of a drug and its biological activity. The following parts are examined : structural modifications of known active substances; structure-activity relationships; definition of a pharmacophore, of a prodrug, concept of bioisosterism, importance of the stereochemistry, drug-receptor interaction.
Learning outcomes of the learning unit
The aim of the course is the presentation of the traditional and innovative concepts used in drug design. This course also aims at explaining to the students that the pharmacological and therapeutic activity of a medicinal product is tightly related to its chemical structure. Since most of the drugs found on the market are issued from organic synthesis, this course also allows to demonstrate one of the multiple valorisation possibilities of organic chemistry.
Prerequisite knowledge and skills
Basic knowledge of inorganic and organic chemistry.
Planned learning activities and teaching methods
There is no practical work associated to this course.
Mode of delivery (face-to-face ; distance-learning)
In accordance with the students, who are usually on a training course during the second semester, the lessons are traditionally given on afternoon per week, from 14h00 to 15h30 and from 15h45 to 17h15 (february-march) during five weeks.
Recommended or required readings
Written notes are distributed to the students during the first lesson.
Assessment methods and criteria
A written exam on the theoretical part of the course.
An oral exam consisting of a discussion on a scientific article devoted to medicinal chemistry distributed to the students during the last lesson.
Work placement(s)
none
Organizational remarks
none
Contacts
Bernard PIROTTE, professeur ordinaire Laboratoire de Chimie Pharmaceutique, Bât. B36, Quartier Hôpital, 15, Avenue Hippocrate, C.H.U. - Tour 4 - niveau +5 - Sart Tilman, B-4000 Liège Tél. : + 32/(0)4/366.43.65 - Fax : + 32/(0)4/366.43.62 - e-mail: B.Pirotte@uliege.be
Adaptation of teaching commitments following the COVID-19 pandemic for the May-June 2020 session
Teaching methods implemented : distance-learning
Provision of written notes for the last parts of the theoretical course, as well as a video on a concrete example of research in medicinal chemistry in collaboration between the university and the pharmaceutical industry.
Assessment subjects
The evaluation will focus on the content of the theoretical course (course notes distributed at the beginning of the teaching) and to the understanding as well as the short oral presentation of a scientific article dedicated to the discovery of drugs.
Assessment methods
The evaluation will be done remotely in the form of an oral exam by videoconference during which the student will present in ten minutes the content of the scientific article received for this exam, followed by an interrogation about the content of the article as well as the content of the theoretical course (30 minutes in total).
Contacts
Bernard PIROTTE (b.pirotte@uliege.be) 0476 30 55 14
Adaptation of teaching commitments following the COVID-19 pandemic for the Aug-Sept 2020 session
Assessment subjects
The evaluation will focus on the content of the theoretical course (course notes distributed at the beginning of the teaching) and to the understanding as well as the short oral presentation of a scientific article dedicated to the discovery of drugs.
Assessment methods
The evaluation will be done remotely in the form of an oral exam by videoconference (lifesize) during which the student will present in ten minutes the content of the scientific article received for this exam, followed by an interrogation about the content of the article as well as the content of the theoretical course (30 minutes in total).
Contacts
Bernard PIROTTE (b.pirotte@uliege.be) 0476 30 55 14