Immunology and vaccinology

Duration

25h Th

Number of credits

Lecturer

Catherine Sadzot

Language(s) of instruction

French language

Organisation and examination

Teaching in the second semester

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

1: Basis of innate immunity - Immune cells involved in pathogen recognition - Expression and control of innate immune defense genes - Transduction pathways and recognition motives - Pathogen-associated molecular patterns - Danger-associated molecular patterns - Innate immune response receptors - Inflammasome and sterile inflammation - Virus recognition and viral interference
2: Inflammation -Basis of the inflammatory reaction - Consequences of the inflammatory reaction - Out of control inflammatory reaction, chronicity - Activation and modulation of the adaptative response: importance of the innate response
3: Principles of vaccine design - Discovery of vaccination - Modern approaches of vaccination - Antigen processing - Adjuvant concept - Mucosal immunity - Animal models for vaccination
4: Vaccinal antigen discovery and their engineering - Bio-informatic, proteomic and phage display libraries - Attenuated microbial vaccines - Virus-like particles - Recombinant vaccines
5: How to deliver a vaccine and how to evaluate its activity - Trans-cutaneous immunisation and injection without needle - Oral vaccines - Biodegradable microparticles - Advantages and drawbacks of multivalent vaccines - Strategies and clinical follow-up - Efficacy evaluation - Safety - Ethical concerns

Learning outcomes of the learning unit

Gain a preliminary view on the innate immune response and its importance in vaccination

Prerequisite knowledge and skills

Prerequisite in immunology, microbiology and molecular biology

Planned learning activities and teaching methods

Oral lessons. Depending on the number of registered students, other learning activities will be undertaken.
Of importance and if possible, lectures could be given by a scientist working in a vaccine company.

Mode of delivery (face-to-face ; distance-learning)

face-to-face

Recommended or required readings

Vaccinology: Principles and pratice by John Morrow et al.
Wiley press
 
Powerpoint presentations used for the lectures will be available on MyULg

Assessment methods and criteria

Oral presentation based on a publication related to a vaccination issue

Work placement(s)

Organizational remarks

None

Contacts

C. Sadzot
Laboratoire de Virologie et d'Immunologie,
GIGA B34 2° floor (Office at the 5° floor)
csadzot@ulg.ac.be
+32 4 366 24 45