2018-2019 / BICP2111-2

Academic program

Seminars on medical chemistry

Seminars on microbiology and infectiology

Seminars on hematology

Seminars on medicamentous toxicology

Blood group serology

Biostatistics II

Multivariate statistical analysis

Study of the human genome in normal and pathological methods of molecular biology

Quality insurance

Duration

Seminars on medical chemistry : 25h Th, 120h SEM
Seminars on microbiology and infectiology : 25h Th, 120h SEM
Seminars on hematology : 25h Th, 120h SEM
Seminars on medicamentous toxicology : 15h Th, 120h SEM
Blood group serology : 15h Th, 90h Pr
Biostatistics II : 15h Th, 15h Pr
Multivariate statistical analysis : 10h Th, 10h Pr
Study of the human genome in normal and pathological methods of molecular biology : 10h Th, 10h Pr
Quality insurance : 10h Th, 10h Pr

Number of credits

 Specialised master in clinical biology ((sciences de la santé))10 crédits 
 Specialised master in clinical biology ((sciences pharmaceutiques))10 crédits 

Lecturer

Seminars on medical chemistry : Collégialité
Seminars on microbiology and infectiology : Marie-Pierre Hayette, Pierrette Melin
Seminars on hematology : André Gothot
Seminars on medicamentous toxicology : Corinne Charlier
Blood group serology : Mélanie Monfort
Biostatistics II : Anne-Françoise Donneau
Multivariate statistical analysis : Anne-Françoise Donneau
Study of the human genome in normal and pathological methods of molecular biology : Vinciane Dideberg, Frédéric Lambert
Quality insurance : Collégialité

Coordinator

N...

Language(s) of instruction

French language

Organisation and examination

All year long, with partial in January

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

Seminars on microbiology and infectiology

Lectures and workshops are compulsory and must be attended either during the first or second year of specialized master according to the geographical location of their internship. They can develop through this cursus their basic knowledge in microbiology and also their critical interpretation of results.
Course in clinical parasitology and mycology (M.P. Hayette) 
The course will include presentation of parasitological and mycological infections and also clinical cases. The programme e-MEDICIN image can be used as support from clinical cases and real cases from the lab will be also included. The students will have also to do a presentation on a topic of their choice.

Table of contents
Part I. General content. 
Mycology: generalities on fungi: structure, host-fungus interaction, prevention and treatment.
Parasitology: generalities on blood and intestinal parasites, host-parasite relationship, prevention and treatment.
Part II. Biological diagnosis.
Invasive and superficial diagnosis: candidosis, cryptococcosis, aspergillosis, pneumocystosis, dermatophytosis.
Blood parasite infections: malaria, toxoplasmosis, filariosis, trypanosomiasis, leishmaniasis. 
Intestinal parasitosis: helminthiasis, amibiasis, giardiasis.

Course and workshops of clinical microbiology (P.Melin)

Seminars on hematology

Hematology is the study of cellular and molecular elements of the blood. The course is dedicated to the physiopathology of hematological illnesses and the laboratory tests used for their diagnosis.

Seminars on medicamentous toxicology

Specific cursus on chromatographic methods in a clinical, forensic and environmental toxicology department.
The students will stay for a 2 - 3 monthes in the lab and participate to technical validations, protocol signatures, etc....

Biostatistics II

This course is the second part of the teaching of Biostatistics at the Faculty of Medicine. It addresses more advanced statistical methods, such as one-way and two-way analysis of variance (ANOVA), contingency tables,  non-parametric statistical techniques and survival analysis.
Each lesson consists of a theoretical exposition of the method followed by a session of practical applications with SAS software, where the student will get used to solve statistical problems encountered in daily practice.

Biostatistics II

This course is the second part of the teaching of Biostatistics at the Faculty of Medicine. It addresses more advanced statistical methods, such as one-way and two-way analysis of variance (ANOVA), contingency tables,  non-parametric statistical techniques and survival analysis.
Each lesson consists of a theoretical exposition of the method followed by a session of practical applications with SAS software, where the student will get used to solve statistical problems encountered in daily practice.

Multivariate statistical analysis

The course is a general introduction to the explicative methods used in multivariate analysis, i.e. the study of several variables simultaneously. The course will cover the following chapters:






  • R introduction
  • Multiple regression
  • Binary and ordinal logistic regression
  • Survival curves and Cox regression
 

Learning outcomes of the learning unit

Seminars on microbiology and infectiology

Parasitology-Mycology


  • To know the main characteristics of fungi and parasites
  • To know all the diagnostic methods for the diagnostic of invasive and superficial fungal or parasitological infections.
  • To develop their debating skills and knowledge to synthesize the literature on a given topic.
Clinical microbiology
At the end of the course, the future specialist will be able to:




  • determine what is a useful clinical result.
  • explain the expected benefit of microbiological analysis in the clinical management of a patient or for setting public health precautions.
  • argue the importance to reducing TAT whenever it is possible
  • argue about and justify preanalytical conditions specific to microbiological analysis.
  • explain the limits of microbiological  diagnostic analysis.
  • propose appropriate diagnostic analysis per type of pathogen/infection.
  • encourage and set dynamic communication with clinicians
  • present the different methods used as diagnostic tools in clinical microbiology according to a syndromic approach
  • sustain a discussion about the different antimicrobial susceptibility testing methods
  • interpret the results of a basic menu of serological tests
  • perform a basic menu of microbiological analysis

Seminars on hematology

1. physiology of hematopoiesis and normal blood cells
2. pathology of red blod cells
3. pathology of white blood cells
4. pathology of platelets
5. hemostasis and coagulation

Biostatistics II

The course is intended to improve and enhance the use of biostatistics in health sciences, by insisting on statistical reasoning and problem solving rather than on the mathematics and the complexity of formula. Students should be able to carry out an in-depth statistical analysis of a dataset resulting from an experiment or a survey, in particular with respect to the thesis they will prepare later on in their cursus.

Multivariate statistical analysis

The course is an introduction to the methods of multivariate data analysis. At the end of the course, the student should have the ability of defining a multivariate problem, analysing the data and interpreting the results. He/she should also be able to understand the use of multivariate methods in the scientific literature.

Prerequisite knowledge and skills

Seminars on microbiology and infectiology

Masters in pharmacy of medecine.

Seminars on hematology

Human and pathological biochemistry. Histology.

Biostatistics II

Prerequisite: STAT1001-1 or some equivalent statistical course.

Multivariate statistical analysis

Prerequisite: STAT1001-1 et STAT0420-1 ou STAT730-2
A good knowledge of univariate statistical methods.

Planned learning activities and teaching methods

Seminars on microbiology and infectiology

  • Ex-cathedra
  • e-MEDICINimage
  • Oral presentations by students
  • Quiz on specific topics
  • Work sessions with clinical cases.

Seminars on hematology

online course.

Biostatistics II

Total: 15 hours
In statistics, practice is most important. Students are therefore requested to attend the practicals. 

Multivariate statistical analysis

The practical sessions consist in analysing mulltivariate datasets by means of the statistical package R.

Mode of delivery (face-to-face ; distance-learning)

Seminars on microbiology and infectiology

Face-to-face and distance learning
Slides and websites will be available for the students

Seminars on hematology

Online course.

Biostatistics II

 All courses will take place at Salle informatique Lapière (CHU, B36) during the first four months.

Multivariate statistical analysis

Each course consists of theory and exercises with R.The homeworks can be completed at home by the student.

Recommended or required readings

Seminars on microbiology and infectiology

Notes as a slideshow Scientifics papers
Recommended books:

  • Moisissures-Dermatophytes-Levures. Chabasse D. et al. Biomérieux Ed. 2005
  • Médecine tropicale. Marc Gentilini. Flammarion Ed. 2005
  • Fungal infection. Diagnosis and management. Richardson and Warnock. Wiley-Blackwell Ed. 2012
  • Bactériologie médicale - Techniques usuelles  2ème édition  François DENIS, Marie-Cécile Ploy, Christian Martin, Edouard Bingen, Roland QUENTIN Editeur: Elsevier Masson. 11/2011 ISBN: 9782294096686 
  • Numerous files, papers concerning varied domains of microbiology can be found on the ASM website (American Society of Microbiology) A consulter et télécharger du site de l'ASM : http://clinmicro.asm.org/index.php/bench-work-resources
  • The  Cumitech series provides consensus recommendations regarding the judicious use of clinical microbiology and immunology laboratories and their role in patient care. Each Cumitech is written by a team of clinicians, laboratorians, and other interested stakeholders to provide a broad overview of various aspects of infectious disease testing. These aspects include a discussion of relevant clinical considerations; collection, transport, processing and interpretive guidelines; the clinical utility of culture-based and non-culture-based methods and emerging technologies; They are edited and published by the ASM.

Seminars on hematology

Distribution of slides presented during the lessons.

Biostatistics II

Slides and databases will be available to the students

Textbook P. Dagnelie. Statistique Théorique et Appliquée. De Boeck Université, Bruxelles, 1999. D. Schwartz. Le jeu de la science et du hasard. La statistique et le vivant. Flammarion, Paris, 1994. D.G. Altman. Practical statistics for medical research. Chapman & Hall, London, 2000.

Multivariate statistical analysis

Slides and databases will be available for the students 
Textbooks (notmandatory) are: -"Analyse statistique multivariée", A. Albert, édition 2011  - Multivariate statistical methods. D. Morrison, Mc Graw-Hill,Auckland, 1986 - Introduction to multivariate analysis. C. Chatfield et A.J. Collins, Chapman and Hall. ed, London, 1980

Assessment methods and criteria

Seminars on microbiology and infectiology

Oral presentations (50%) Exam (orally) (50%)

 

Seminars on hematology

Oral exam by opened questions selected among a list communicated to the students at the end of the course. True/false questions on the whole course content.

Biostatistics II

A written test will take place in January and last about 3hours. 

Multivariate statistical analysis

Practice exam on computer. It will take place in January and last about 2 hours.

Work placement(s)

Seminars on microbiology and infectiology

Six months in the laboratory of medical microbiology during the first two years.

Organizational remarks

Seminars on microbiology and infectiology

Schedule defined between the lecturer and the participants

Multivariate statistical analysis

The course will normally take place on Wednesday morning of the first quadrimester.

Contacts

Seminars on microbiology and infectiology

Clinical Microbiology Department University Hospital of Liège, B-23 Sart Tilman, 4000 LIEGE Belgium
Secretary
For any contact or to fix an appointment, please contact the secretary Mrs MC Lhote



  • Phone : 00.32.4.366.24.39
  • Telecopy: 00.32.4.366.24.40
  • email : micromed@uliege.be
Professors and lecturers
Prof. Pierrette Melin Pierrette.Melin@uliege.be
Prof. Marie-Pierre Hayette mphayette@uliege.be
Others lecturers
Julie Descy, Pharmacist specialist in clinical biology julie.descy@chuliege.be
Dr.Pascale Huynen, MD specialist in clinical biology  p.huynen@chuliege.be
Cécile Meex, Pharmacist specialist in clinical biology              c.meex@chuliege.be

Seminars on hematology

Hematobiology and Immuno-Hematology

CHU, Tower 2, 6th floor, room 19.

Tel: 04/366 75 36 (Mrs Henet)

e-mail: hematobio@ulg.ac.be

Seminars on medicamentous toxicology

Prof. Corinne CHARLIER
Service de toxicologie clinique, médicolégale, de l'environnement et en entreprise
Bloc central +3 porte 166 CHU
Tél secrétariat 04/3667683 Toxclimedileg@chu.ulg.ac.be
Assistants : Raphaël DENOOZ, Virginie MISTRETTA

Biostatistics II

* Anne-Françoise DONNEAU (Professor), Quartier Hôpital, Avenue Hippocrate, 13 - Bât 23, 4000 Liège - Belgique. Tél: 04-366.47.90 Email: afdonneau@uliege.be 

* Assistant : Nadia DARDENNE, Quartier Hôpital, Avenue Hippocrate, 13 - Bât 23, 4000 Liège - Belgique - Tél: 04-366.33.40 - Email:ndardenne@uliege.be

Multivariate statistical analysis

* Anne-Françoise DONNEAU (Professor), Quartier Hôpital, Avenue Hippocrate, 13 - Bât 23, 4000 Liège - Belgique. Tél: 04-366.47.90 Email: afdonneau@uliege.be  

* Assistant : Nadia DARDENNE, Quartier Hôpital, Avenue Hippocrate, 13 - Bât 23, 4000 Liège - Belgique - Tél: 04-366.33.40 - Email:ndardenne@uliege.be