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| BIOL2021-1 | Theory of the molecular structure-function relations
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| Duration : | 24h Th |
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| Language : | French language |
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| Course contents : | Four steps are successively covered:
Step 1 describes the chemical properties of the molecules of the living world
Step 2 analyses in details the energy functions involved in the structure of biological molecules and macromolecules
Step 3 describes the status of the experimental knowledge of the three-dimensional structure of the molecular components of the living cell
Step 4 covers the present methods of prediction of structure and function ofmolecules involved in the cell life
At the end of the course the student should possess a good knowledge of the techniques used and a view structure-function relations. The importance, but also the limitations of the present knowledge and the efforts to reach a better understanding of the molecular mechanisms should lead him, in the whole of his scientific work, to further consider the structural mechanisms involed. |
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| Course objective : | Demonstrate to the students that the structure of the molecules (lipids, proteins, nucleic acids) and their function are intimately related
After completing the course the student is expected to
- expose and synthetize chemical and structural properties of macromolecules
- understand and explain the role of the various energies involved in the stabilisation of macromolecule structure
- synthetize and compare the various techniques dedicated to analyze the macromolecule structure-function relationship
- understand and criticize a scientific paper about protein structure and function |
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| Prerequisites : | Basic knowledge of organic chemistry, chemical structure of amino acids, secondary structure of proteins |
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| Organization : | Lectures : 24h |
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| Written notes : | L. Lins and R. Brasseur, FASEB J.9 (1995) 535-540
T. E. Creighton, Proteins, Structures and molecular properties, W. H. Freeman and Company, New-York (1993) |
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| Assessment : | Oral examination (66%)
Personal report (34%) |
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| Contacts : | Brasseur, Robert (FNRS Research Director, CBMN Director)
Center for Numerical Molecular Biophysics
081 62 25 21
rbrasseur@ulg.ac.be |
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