Duration
42h Pr
Number of credits
| Bachelor in pharmacy | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The Pharmaceutical Analytical Chemistry laboratory sessions are designed to complement the theoretical lectures and seminars associated with the Pharmaceutical Analytical Chemistry course (Part II, CHIM9332-1). They constitute the natural continuation of the modules introduced during the previous semester (CHIM0321-3).
In this second part, you will work directly with analytical instruments such as an HPLC-UV system, a GC-FID system, and a flame atomic absorption spectrophotometer. These practical sessions correspond to Module 3, entitled Comparative Methods.
The final module, Module 4: Integration, will focus in particular on the use of a portable near-infrared (NIR) spectroscopic system. The aim of this module is to illustrate several technical aspects previously addressed from a theoretical perspective and to further develop your analytical thinking. In particular, you will be encouraged to critically assess the most appropriate analytical technique and calibration strategy according to the analytical problem under investigation.
Laboratory sessions will be conducted in groups, according to an allocation schedule that will be provided on the eCampus platform.
Learning outcomes of the learning unit
Throughout the laboratory sessions, you will develop new competencies that build upon the following learning outcomes:
Pharmaceutical Expertise Students will be able to:
- Solve analytical problems of a level comparable to those addressed during the laboratory exercises.
- Understand the pharmaceutical applications of the raw materials handled during these practical sessions.
- Justify the selection of an analytical technique appropriate for the analyte under investigation, taking into account the analytical context.
- Identify and record relevant data in a laboratory notebook.
- Determine an appropriate calibration strategy for a given analytical problem, in connection with the concepts covered in the theoretical course.
- Demonstrate a thorough understanding of the concept of an internal standard.
- Demonstrate a thorough understanding of the concept of a chemical reference substance.
- Accurately implement a more complex protocol.
- Identify the critical parameters specific to each analytical technique covered during the laboratory sessions.
- Collaborate effectively within a team to distribute and coordinate tasks.
- Generate accurate results from comparative analytical methods.
- Evaluate the accuracy of quantitative analytical results while considering potential sources of error.
- Communicate scientific results in a structured report following the format of a scientific article.
- Collaborate effectively with fellow students during laboratory sessions.
- Contribute actively to teamwork by sharing responsibilities in order to achieve a common objective.
- Apply a peer-based double-checking approach to ensure the reliability of analytical results.
- Demonstrate transparency and accountability by reporting any observed errors to the team.
- Apply Good Laboratory Practices
- Propose and justify an analytical procedure based on a given analytical context, drawing on concepts covered in the theoretical course.
- Respond appropriately to experimental errors and adapt the analytical approach in order to ensure the reliability of the results and the continuation of the analysis.
Prerequisite knowledge and skills
Before undertaking the Pharmaceutical Analytical Chemistry practical sessions, you are expected to have a solid background in chemistry and to have successfully completed the courses CHIM0748-3 and CHIM9326-1.
Moreover, completion of the Pharmaceutical Analytical Chemistry Part I course (CHIM0320-3) and the parctical works of Pharmaceutical Analytical Chemistry (CHIM0321-3) is a prerequisite.
Wherever feasible, and in order to maintain the pedagogical coherence of the course design, it is recommended that students enrol in both the lectures and the corresponding laboratory sessions within the same Individual Study Programme.
Planned learning activities and teaching methods
The laboratory component of this course is organised as follows:
The practical sessions will be introduced through two preparatory lectures held in a lecture hall. Their purpose is to provide guidance for the different laboratory sessions by reviewing and explaining the various experimental procedures.
The first laboratory session, to be conducted individually, focuses on the analysis of a sample. Students will employ spectroscopic and colorimetric methods for identification purposes, as well as a titrimetric method for quantitative analysis. This session will enable students to compare the relevance, advantages, and limitations of the analytical methods employed.
The remaining laboratory sessions will be carried out in groups using a range of analytical instruments, including HPLC-UV, AAS, GC-FID, and near-infrared (NIR) systems. These sessions will allow students to gain insight into the operating principles of these techniques and to perform the different stages of an analytical procedure with rigor, while applying the theoretical concepts covered during the lectures. Particular attention will be paid to the critical parameters associated with each analytical technique and to the appropriateness of the selected calibration strategy.
In addition, three seminars are scheduled during the semester. The material covered in these seminars forms an integral part of the knowledge and competencies required for successful participation in the laboratory sessions.
Continuous assessment during the semester:
The following assessments will be conducted throughout the semester:
- Three tests focusing on the content of the laboratory sessions and seminars.
- For each analytical technique, students will be required to submit an analytical report via eCampus, structured according to the format of a scientific article. One grade will be awarded for the quality of the report, and a separate grade will be assigned to the final analytical result obtained by the group.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Further information:
Practical work are organized in the student laboratory of the Pharmacy Department (CHU, Tower 4, +4 level)
The attendance at practical work and associated activities (seminars, explanations,...) is compulsory. Any absence must be notified by a email just before the course or practical work and justified by sending an official document legally recognized in its country of issue to Dr. De Bleye (cdebleye@uliege.be) and Madam Saker (b.saker@uliege.be) in 24h.
An attendance à 80% of all activities is compulsory to attend to the examen in first and second session.
Course materials and recommended or required readings
Platform(s) used for course materials:
- eCampus
Further information:
The eCampus platform provides access to the practical manual and PowerPoint presentations.
You will also find on the eCampuis platform:
- A graphic syllabus offering a visual overview of all activities scheduled throughout the semester
- A detailed program of activities
- Group compositions
No reference book is required to complete the practical sessions and associated activities. For further explanations, students may refer to the Pharmaceutical Analytical Chemistry Part I and II theoretical courses (CHIM0320-3 and CHIM9332-1).
For additional or differently presented information, students may consult the Mémo Visuel de Chimie Analytique (Dunod, 2020), available at the Life Sciences Library (CHU de Liège campus)
Exam(s) in session
Any session
- In-person
written exam
Written work / report
Continuous assessment
Out-of-session test(s)
Further information:
During the semester:
- Practical sessions: 40% of the final grade
- Tests: 30% of the final grade
Exam:
The exam represents 30% of the final grade. This written exam assesses the integration of all course content.
Second session:
In the secobd session, the final grade is based on two components:
- The grade obtained for the year's practical work (40%), which is carried over
- A written exam (60%) consisting of questions similar to those in the tests and the exam of the first session
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Charlotte De Bleye, 1ère Assistante
Service de Chimie Analytique Pharmaceutique, Département de Pharmacie, CHU Bât. B36, Quartier Hôpital,avenue Hippocrate 15, 4000 Liège 1
Tél : +32 4 366.43.18
e-mail : cdebleye@uliege.be
Beyza Saker, Assistante
Service de Chimie Analytique Pharmaceutique, Département de Pharmacie, CHU Bât. B36, Quartier Hôpital,avenue Hippocrate 15, 4000 Liège 1
e-mail : b.saker@uliege.be
Sébastien Lhoest, Technicien
Service de Chimie Analytique Pharmaceutique, Département de Pharmacie, CHU Bât. B36, Quartier Hôpital,avenue Hippocrate 15, 4000 Liège 1
Tel. : 04/366.43.23
e-mail: slhoest@uliege.be
Eric Ziemons, Chargé de cours
Service de Chimie Analytique Pharmaceutique, Département de Pharmacie, CHU Bât. B36, Quartier Hôpital,avenue Hippocrate 15, 4000 Liège 1
Tel. : 04/366.43.15
e-mail: eziemons@uliege.be