Duration
50h Th
Number of credits
| Master in chemistry, research focus | 5 crédits | |||
| Master in chemistry, teaching focus (Réinscription uniquement, pas de nouvelle inscription) | 5 crédits | |||
| Master in chemistry, professional focus | 5 crédits |
Lecturer
Christian Damblon, Anne-Sophie Duwez, Gauthier Eppe, Jean-François Focant, Loïc Quinton
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
"Emerging Analytical Approaches"
The course "Emerging Analytical Approaches" builds on your previous coursework in analytical chemistry. Its aim is to complete your training by addressing analytical challenges in a concrete and illustrated manner. Several general themes will be covered, drawing on concepts previously introduced during your bachelor's cycle as well as on additional concepts from modern analytical chemistry. The course will be taught by a group of instructors who are experts in cutting-edge fields of analytical chemistry.
The two main themes addressed will be the analysis of small molecules and molecular imaging in fields such as medicine, the environment, and food products.
Non-exhaustively, these two themes will cover the following aspects:
Gas chromatography (one- and multi-dimensional), liquid chromatography, and mass spectrometry
A. Multi-dimensional couplings
B. Quantitative analysis of small molecules
C. Sampling and introduction methods
D. GC-MS, GC-MS/MS, and GCxGC-TOFMS
E. LC-MS, LC-MS/MS, and LC-TOFMS
F. Case studies in volatilomics and metabolomics
G. Case studies in food quality control
H. Laboratory activity (analysis of blood plasma by GC-MS, LC-MS, and NMR)
Mass Spectrometry Imaging (MSI) - Focus on lipid analysis
A. Introduction and review
B. Fundamentals of mass spectrometry
C. Principles of mass spectrometry imaging
D. First steps in lipidomics
E. Data analysis - Why and how - By Dr. Ellis Shane, M4I, Maastricht University
F. Hands-on work: record your first MALDI-TOF image of a mouse brain!
Raman Spectroscopy Imaging (RSI) - Focus on lipid analysis
A. Introduction and review
B. Principles of Raman imaging and signal processing
C. Hands-on work: record your first Raman image of a mouse brain
D. Integration of MS and Raman approaches, data discussion and interpretation
Atomic Force Microscopy
A. Introduction to scanning probe microscopy techniques
B. Fundamentals of atomic force microscopy
C. Single-molecule force spectroscopy
D. Applications of force spectroscopy in biology/medicine
E. Laboratory activity
Nuclear Magnetic Resonance
A. Solid-state NMR for the characterization of pharmaceutical materials and formulations
B. In vivo magnetic resonance imaging and spectroscopy
C. Metabolomics and lipidomics by NMR
D. Analysis of complex mixtures by diffusion NMR (DOSY)
E. Laboratory activity in solid- and liquid-state NMR
Learning outcomes of the learning unit
The objective of this course is to describe moden analytical chemistry methods used by the academic world and the industry to answer basic and practical challenges.
Prerequisite knowledge and skills
This course requires a Bachelor level in chemistry.
Planned learning activities and teaching methods
This unit will be made of theoretical courses given by the professors in charge and completed by external speakers from academia and industry. Hands on practical exercices will also be carried out for some specific thematics.
Mode of delivery (face to face, distance learning, hybrid learning)
Courses will be delivered in classrooms and laboratories.
Course materials and recommended or required readings
This will be discussed in due time.
The exams wil lbe made of written open questions and possibly MCQ and T/F questions. This could also be completed by an oral exam where the concepts used to answer the written exam wil be discussedin more details.
Work placement(s)
Not relevant
Organisational remarks and main changes to the course
Details on the format of the different courses will be communicated in advance.
Contacts
Jean-François (Jef) Focant Full Professor University of Liège Organic and Biological Analytical Chemistry - MOLSYS Allée du 6 août, 11, B6c, Quartier Agora B-4000 Liège (Sart-Tilman) Belgium Ph: +32 (0)4 366 35 31 Cell: +32 (0)495 92 95 64 Fax: +32 (0)4 366 43 87