2024-2025 / CHIM0746-1

Nuclear chemistry and introduction to labeling and imaging techniques

Duration

50h Th

Number of credits

 Master in chemistry, research focus5 crédits 
 Master in chemistry, teaching focus5 crédits 
 Master in chemistry, professional focus5 crédits 

Lecturer

Thibault Gendron

Language(s) of instruction

English language

Organisation and examination

Teaching in the second semester

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

Radioactivity plays an important role in our modern daily life. Chemistry is pivotal in taming this phenomenon for practical use in e.g. nuclear medicine or electricity production. This course aims at introducing and teaching you these two very specific experimental sciences that are nuclear chemistry and radiochemistry.

Course outline:

I. Introduction - Radioactivity
II. Nuclear Reactions
III. Electricity production
    - Nuclear Power Plant
    - Nuclear Waste treatment
IV. Nuclear Medicine
    - Design and structural features of a radiopharmaceutical
    - Covalent radiolabelling: 11C, 18F, and iodine
    - Chelation radiolabelling: 68Ga, 89Zr, 99mTc, 117Lu
    - Radionuclide Selection Guide for the design of radiopharmaceutical
    - Nomenclature
    - Daily life of a radiochemist: practical example of a production centre
V. Notions of radioprotection

Learning outcomes of the learning unit

At the end of this course, you will know what is radioactivity and the different type of nuclear reactions. You will have a reasonnable knowledge of how a nuclear power plant works and of the nuclear waste topic. You will also have a better understanding of the whole radiopharmaceutical production pipeline and where chemistry play a part. You will know the general categories of radiolabelling reactions. You will have a better understanding of the challenges to tackle for the futur of Nuclear Medicine.

Prerequisite knowledge and skills

Master level chemistry.

Planned learning activities and teaching methods

Mode of delivery (face to face, distance learning, hybrid learning)

Face-to-face course


Additional information:

This course has 12 lectures delivered during the second semester

Course materials and recommended or required readings

Lecture presentations are accessible online on myULiege.

Reading material:

Nuclear and radiochemistry : fundamentals and applications, LIESER. Berlin : Wiley-VCH, 2001

Radiopharmaceutical Chemistry, J. S. Lewis, A. D. Windhorst, B. M. Zeglis, Springer Nature, 2019, ISBN 978-3319989488

Chimie des radiotraceurs et applications biologiques, M. Comet et M. Vidal. EDP Science, 1998, ISBN: 2-86883-460-4

Oral exam

Work placement(s)

Organisational remarks and main changes to the course

Contacts

Thibault Gendron

Bât. B30 Centre de Recherche du Cyclotron
Quartier Agora
allée du Six Août 8
4000 Liège 1

Association of one or more MOOCs