Duration
25h Th
Number of credits
| Bachelor in physiotherapy and rehabilitation | 4 crédits | |||
| Bachelor in motor sciences | 4 crédits |
Lecturer
Substitute(s)
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Teacher : S. WISLET, Associate Professor
The aim of biochemistry is the complete understanding at the molecular level of all the chemical processes associated with living cells. This is mainly achieved by isolating molecules and understanding their structure and their function. The field of biochemistry is as vast as life itself, as chemical reactions take place wherever life exists. Biochemists study the chemical reactions and changes which take place in micro-organisms, plants, fish, insects, lesser and superior mammals like human beings.
Biochemical knowledge of other forms of life is directly relevant to a global understanding of the biochemistry of human beings. For example, current theories on the regulation of gene and enzyme activity come from earlier studies of bread yeast and bacteria. Like general physiology, general biochemistry demonstrates the integrated unity of living beings.
This course is devoted to the understanding of the organism's molecular structure, of the notion of metabolic sequences, of the rules governing the integration of these sequences, of the general basics of cell energy, of the source of inter-cellular free energy, and finally, of the biochemical tissue specialization. Examples illustrating taught concepts will be specifically chosen to introduce the student to human biochemistry.
Learning outcomes of the learning unit
General objectives :
To describe the general properties of molecules composing the living species.
To give a clear and structured information about the chemical reactions within the cell.
To analyse the relationships between these different molecules.
To explain how the cell structure is maintained and expanded or how the cell can achieve a particular function.
To allow the students to understand the biochemical basis of general physiology and human physiology and biochemistry.
To exert the critical thinking of students by pro or contra demonstrations on different subjects or debate some not yet verified hypothesis.
Specific objectives :
1. To describe the general properties of the molecules of living beings : carbohydrates, lipids, amino acids, peptides, proteins, nucleic acids, heterocycles (co-enzymes, vitamins, nucleosides, ...)
2. To understand the basics of classical enzymology (kinetics, enzyme classification, reaction mechanisms, ...).
3. To remember the basics of thermodynamic laws and to apply them to specificities encountered in the living world: high energy molecules, the coupling reactions, ... .
4. To explain the general organization of the main metabolic pathways in cells by integrating them each others and to outline the basics of the controls of metabolic pathways.
5. To describe in details the cellular catabolic reactions leading to the synthesis of high-energy molecules.
6. To describe in details anabolic pathways leading to the synthesis of nucleotides, nucleic acids, proteins, lipids and carbohydrates.
7. To apply and to integrate those concepts in the mechanisms of muscle contraction
Prerequisite knowledge and skills
First year courses in physics, chemistry (more precisely, organic chemistry) and biology. To prepare students to the study of human biochemistry, human physiology and to the pathology.
Planned learning activities and teaching methods
Lectures will be ex cathedra.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Further information:
1: Introduction to chemical reactions in a living cell.
1. Chemistry, Energy and Metabolism
2. Enzymes
2: Structure of proteins and cell membranes.
3. Protein structure
4. Cell Membranes
3: Metabolism
5. Biochemical mechanisms of nutrient transport and storage
6. Energy release from nutrient oxidation
7. Glycolysis, Krebs'cycle, electron transport in mitochondria.
8. Energy release from lipids
9. Fatty acids and lipids synthesis
10. Neoglucogenesis
11. Pentoses cycle
12. Amino acids metabolism
4. Information storage and use.
13. Nucleotides metabolism and genomes organization
5. Cellular mechanical work.
14. Muscular contraction
15. Cytoskeletton, molecular motors and intracellular transport.
Course materials and recommended or required readings
Platform(s) used for course materials:
- eCampus
Further information:
Actualized Syllabus (2019) is available at Presses Universitaires at a low price.
Students will be able to get a written or an electronic syllabus (available on intranet) on September, the 15th.
They will have also the possibility to download illustrations given during lectures after each lectures.
The lectures themselves will be recorded and easy available in Intranet (pod-cast). Students can send by e-mail questions.
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire )
Further information:
Exam(s) in session
Any session : written exam ( multiple-choice questionnaire)
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Sabine Wislet
Professeur Associée, Agrégée Biochimie et Physiologie
Tél. ULg : 32 4 366 38 04
Couriel : S.Wislet@uliege.be
Larisia Bourdoux
Secrétaire
Tél ULg : 32 4 366 59 50
Couriel : Larisia.Bourdoux@uliege.be