2023-2024 / IMMU0230-1



10h Th

Number of credits

 Bachelor in dentistry1 crédit 


Olivier Malaise, Michel Moutschen

Language(s) of instruction

French language

Organisation and examination

Teaching in the first semester, review in January


Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

The course will be given by Prof. Olivier Malaise (in collaboration with M. Moutschen)


This course will present the main principles of immunopathology which must be known by all future health professionals: it will thus approach the classical general concepts of autoimmune pathology, hypersensitivity reaction, anti-infectious immunity and immune deficiency.

It will also emphasize three points of particular importance in the current daily practice of future health practitioners: the concepts of vaccination (including vaccinations against Covid), immunosuppressive drugs (selective or non-selective, whose use is increasingly wide) and the aging of the immune system (parallel to the aging of the population, through the concept of immuno-senescence).

It is also important that the course is relevant to the practice of future dentists. First of all, the oral cavity presents immunological particularities compared to other organs: the course will have to begin, by taking advantage of a brief recall of general immunology, by the presentation of the immunological particularities of the various tissues, like the periodontium or the osseous niches (through the concept of osteo-immunology). The exemplary pathologies that will illustrate the concepts of the course will be chosen among pathologies involving the dental sphere. For example, reactions to amalgam or local anaesthetics will illustrate the course on hypersensitivities and rheumatoid arthritis, whose trigger is the citrullination of certain proteins in the periodontium, will illustrate the course on autoimmune pathologies.

  • General introduction and immunological particularity of the oral sphere
  • Anti-infectious immunity adapted to the oral sphere                                          
  • Pathophysiological mechanism of autoimmune diseases                                           
  • Hypersensitivity reaction                                                                                 
  • Primary and acquired immune deficiencies                                                              
  • Immunosuppressive drugs
    Cellular and humoral rejection reaction                                                                 
  • Principles of vaccination                                                                                      
  • Aging of the immune system                                                                 
  • Synthesis and preparation for exam questions                                                          

Learning outcomes of the learning unit

Learning objectives of each lecture will be summarized at the beginning of each slide kit (available on E-campus)

Prerequisite knowledge and skills

Planned learning activities and teaching methods

Five two-hour lectures

Mode of delivery (face to face, distance learning, hybrid learning)

Face-to-face. Slide kits are also available on E campus. Students are also welcome to meet me personnally for further discussion or questions relative to the lectures

Recommended or required readings

Exam(s) in session

Any session

- In-person

written exam ( multiple-choice questionnaire ) AND oral exam

Additional information:

15 multiple choice questions and oral evaluation

Work placement(s)

Organisational remarks and main changes to the course


Olivier Malaise olivier.malaise@chuliege.be

Secretary : rhumatologie@chuliege.be

Association of one or more MOOCs