2023-2024 / CHIM0620-1

Radiopharmaceutical Chemistry


20h Th, 10h Pr

Number of credits

 University certificate in radiopharmacy - long training3 crédits 
 University certificate in radiopharmacy - short training3 crédits 
 Master in physics (120 ECTS)3 crédits 


Thibault Gendron

Language(s) of instruction

French language

Organisation and examination

Teaching in the first semester, review in January


Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

Modern nuclear medicine relies extensively on the use of radioactive molecules, both for diagnosis and therapy. The design and manufacture of these molecules is the result of innovative experimental research in which chemistry plays a major role. This course aims at teaching you the basic notions of this very specific chemistry called "radiochemistry".

Course outline:

  • Introduction - Nuclear Medicine and Chemistry
  • Structural features and design of a radiopharmaceutical
  • Covalent radiolabelling: 11C, 18F, and iodine
  • Chelation radiolabelling: 68Ga, 89Zr, 99mTc, 117Lu
  • Radionuclide Selection Guide for the design of radiopharmaceutical
  • Nomenclature
  • Daily life of a radiochemist: practical example of a production centre

Learning outcomes of the learning unit

At the end of this course, you will have a better understanding of the whole radiopharmaceutical production pipeline and where chemistry play a part. You will know the general categories of radiolabelling reactions. The main aim of this lecture is to give you the skills and knowledge to be able to discuss and understand radiochemist in your future employment as a radiopharmacist or physicist.

Prerequisite knowledge and skills

Basic general knowledge in chemistry, at least A-level, preferably bechelor level.

Planned learning activities and teaching methods

The lecture will be given in-person; if required and justified, a video conference link may be created to ensure access to the lecture to everyone.

Students will attend a session at the Centre de Recherche de Cyclotron during which they will see a real production of a radiopharmaceutical (subjected to availability).

Mode of delivery (face to face, distance learning, hybrid learning)

This course has 10 lectures delivered during the first semester

Recommended or required readings

Lecture presentations are accessible online on myULiege. Slides will be made available at the begining of each chapter.

For further reading material, please have a look at the following books (these are NOT mandatory for the course):

Radiopharmaceutical Chemistry, J. S. Lewis, A. D. Windhorst, B. M. Zeglis, Springer Nature, 2019, ISBN 978-3319989488

Chimie des radiotraceurs et applications biologiques, M. Comet et M. Vidal. EDP Science, 1998, ISBN: 2-86883-460-4

Exam(s) in session

Any session

- In-person

oral exam

Written work / report

Additional information:

The final examination will be an oral presentation on a topic relevant to the production of radiopharmaceutical. The class will be divided in groups of 2-4 and each group will choose a topic amongst a list given by the lecturer. An abstract, written both in French and English, as well as a group presentation will be assessed.

Work placement(s)

Organisational remarks and main changes to the course


Thibault Gendron, t.gendron@uliege.be

Bât. B30 Centre de Recherche du Cyclotron
Quartier Agora
allée du Six Août 8
4000 Liège 1

Please note that my office is located in a controlled area with access restricted to authorized personal only; you will not be able to pop-up in my office without due appointment. Please send me an email instead, I will gladly respond within 72 hours. If need be, I will then organize an in-person meeting to discuss the matter.

Association of one or more MOOCs