Duration
40h Th, 10h Pr
Number of credits
| Bachelor in pharmacy | 6 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The main goal of this biochemistry course is to provide a broad and comprehensive view of the main biochemical processes occuring in living organisms. These fundamental knowledges should represent solid bases for understanding cell biology, physiology and pathophysiology.
Learning outcomes of the learning unit
To understand the thermodynamic principles applied to biochemistry and understand their implications in the study of metabolism and its regulations
To know the structure of amino acids and their physicochemical properties
To know the structure of polypeptides and proteins, their structural and functional classifications and their main roles in cell
To understand the structure and physiology of hemoglobin, muscle proteins and immunoglobulins
To know and understand the main methods of quantification, identification of amino acids and proteins, and sequencing of polypeptides
To understand the principles of enzymatic catalysisKnow the different classes of enzyme (classification) and understand the concepts of coenzyme, cofactors, prosthetic group, and allosteric effectors
To know the different types of enzyme kinetics, the Michaelis-Menten equation, its application conditions, its mathematical transformations ematics to determine Vmax and Km, and the different inhibitor types.
To understand the principles of allosteric regulation and those of two-substrate kinetics
To know the structure of oses, their cyclization and their derivatives
To understand the mechanism of osidic bonding and know the structure of disaccharides and polysaccharides (homoglycans, heteroglycans and heterosides)
To know the structure of nucleic bases, nucleosides and nucleotides
To know the different classes of lipids, their structure and their role in biochemistry
To understand the structure of membranes, their composition, their functions and their functional topographic specializations
To know and understand the circulation of lipids and the metabolism of lipoproteins
To know and understand the major catabolic pathways (glycolysis, pyruvate crossroads and Krebs cycle), the sequences of the enzymatic reactions that compose them, their regulations and the thermodynamic aspects
Being able to write the stochoimetric equation and calculate the energy yield of the complete oxidation of simple organic compounds via the major catabolic pathways
To understanding the e transport of electrons in the respiratory chain, the transfer of energy in the oxidation-reduction reactions that compose it, and the mechanism of oxidative phosphorylations.
To know the catabolism of amino acids, the transport and detoxification pathways of ammonia (urea cycle)
To know the pathways of glycogen degradation and synthesis, their regulations, and the catabolism of monosaccharides other than glucose
Knowing the pathway of fatty acid catabolism and its energy yield
Understanding the pathways of synthesis of amino acids, hemes and lipids
Knowing and understanding gluconeogenesis, its regulation and the principles of adaptation to fasting
Understanding the pentose shunt and its physiological implication Understanding metabolism
To understand the metabolism of purines, pyrimidines and nucleic acids, and know the mode of action of the main classes of pharmacological molecules that act at this level
To know the mode of action of pharmacological molecules seen in the course of biochemistry
To know the main inborn errors metabolism that illustrate the course
Prerequisite knowledge and skills
Chemistry, Physics and Biology
Planned learning activities and teaching methods
The general biochemistry course includes the theoretical course and practical work sessions (TP). The theoretical courses expose the material and questions from students are strongly encouraged. They include exercise sessions so that the student becomes familiar with the expected requirements in terms of mastery of the subject.
A non-certifying question (optional) is provided at the end of the descriptive biochemistry part (subject of chapters 1-6). A non-certifying question (optional) is provided at the end of the descriptive biochemistry part (subject of chapters 1-6). Practical work sessions take place by group of students and are grouped over one day.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face course
Recommended or required readings
Les diaporamas du cours forment la base de la matière du cours. Ils sont disponibles sur l'espace du cours sur eCampus. Les cours en auditoires sont également podcastés (dans la mesure du possible) et exceptionnellement disponibles en version commentée (sur eCampus). Il n'y a pas de syllabus dédié mais celui du Professeur Rogister (Biochimie générale, disponible aux Presses Universitaires) recouvre l'essentiel de la matière abordée au cours.
Les lectures de plusieurs ouvrages de biochimie peuvent être recommandées mais ne sont pas obligatoire.
- Biochimie 1er cycle, G. Hennen ; Dunod
- Biochemistry, par A.L. Lehninger ; Worth Publischers, Inc. ; New York
-Biochemistry for medical sciences (Newsholme); Willey
- Biochemistry, par L. Stryer ; W.H. Freeman and Company, San Francisco.
- Biochemistry. A functional Approach, par R.W. Mc Giltery et G. Goldstein, Saunders Compagny, Londres.
- Biochimie. D. Voet et J. G. Voet. De Boeck Université.
- Fundamentals at Biochemistry, life at the molecular level, D. Voet, J.G. Voet, C.W. Pratt, Wiley.
Exam(s) in session
Any session
- In-person
written exam ( multiple-choice questionnaire, open-ended questions )
Other : Non certifying test in october (optional)
Additional information:
Un examen prévu en session (janvier - août) comprend des QCM de type vrai/faux généralisés ainsi que des questions ouvertes. La cotation sera de +1 en cas de réponse correcte, 0 en cas d'absence de réponse et -1 en cas de réponse incorrecte. Une partie de l'examen porte plus spécifiquement sur la matière des travaux pratiques.
Work placement(s)
Organisational remarks and main changes to the course
Un syllabus spécifique dédié est en cours de rédaction. Il complete les diaporamas disponibles sur ecampus. Le syllabus complet n'étant pas encore finalisé, les différents chapitres du cours seront postés sur ecampus au fur et à mesure de la progression du cours.
Contacts
F-G. Debray
Service de génétique médicale
CHU Liège Domaine Sart-Tilman Bât B35, B4000 Liège
fg.debray@uliege.be
F. Boemer
Service de génétique médicale
CHU Liège Domaine Sart-Tilman Bât B35, B4000 Liège
f.boemer@uliege.be
Michelle Carlino
Secrétariat de génétique
04/3668145
mcarlino@chuliege.be
Christel Péqueux (TP)
04/3662217
c.pequeux@uliege.be
Association of one or more MOOCs
Items online
CYCLE DE KREBS
CYCLE DE KREBS