2023-2024 / BIOC0722-1

Application of spectroscopic techniques to the study of folding and stability of proteins


20h Th, 10h Mon. WS

Number of credits

 Master in bio-informatics and modelling (120 ECTS)3 crédits 
 Master in biochemistry and molecular and cell biology (120 ECTS)3 crédits 


André Matagne

Language(s) of instruction

French language

Organisation and examination

Teaching in the second semester


Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

This series of lectures is based on the use of biophysical methods (mainly optical spectroscopies, presented into details for course BIOC0721-1: Spectroscopies optiques for biochemistry) to study protein folding and stability. Concrete examples (e.g. bêta-lactamases, single-domain antibody fragments, lysozymes) are analyzed in details, on the basis of theoretical background and data found in the literature. The course starts with an introduction to protein folding (in English).

Learning outcomes of the learning unit

Students will learn how some biophysical methods can be used to study protein folding and stability.

Prerequisite knowledge and skills

General knowledge about proteins and spectroscopic methods

Planned learning activities and teaching methods

Lectures are given with the help of powerpoint presentations, blackboard and white chalk

Mode of delivery (face to face, distance learning, hybrid learning)

Face-to-face course

Additional information:

Due to the 2023-2024 reform of the BBMC Master, this course is no longer organised and is only accessible to students who did not pass the exam before the reform started.

Recommended or required readings

Scientific articles will be given as they are analyzed and synthetic lecture notes will be available following the lectures

An oral will be organized. Each student is given ca. 30 min, with maximum 15 min for preparation and thus minimum 15 min for discussion.

Work placement(s)

Non applicable

Organisational remarks and main changes to the course

Lectures will be organized following the schedule known by the students. The professor will inform the students in advance of any possible modification to this


André Matagne, PhD, Full Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Quartier Agora, Allée du 6 Août, 13, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be

Association of one or more MOOCs