Duration
20h Th, 10h Pr
Number of credits
| Master in biomedicine (120 ECTS) | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Second part of the course on cellular and molecular neurobiology
This course focuses on the cellular and molecular mechanisms involved in the development of the nervous system.
Ten chapters cover some of the most recently described aspects of the following steps of brain development:
- Neural and mesodermal induction
- Polarity and regionalization of the nervous system
- Neural stem cells
- Cellular determination
- Neuronogenesis
- Neuronal migration
- Trophicity and programmed cell death
- Axonogenesis and axonal guidance
- Innervation and synaptogenesis
- Synaptic elimination
Learning outcomes of the learning unit
At the end of this course the student will master the following proficiencies :
1. He will understand how the embryonic neuroepithelium is induced and then partitioned between future divisions of the nervous system, he will know how the plasticity of gene expression, mechanisms of intercellular signaling and of intrinsic differentiation of cells contribute to the polarization and the delineation of future parts of the brain, he will apprehend the evolutionary history of the nervous system through a comparative approach in invertebrates and vertebrates.
2. He will understand how cell populations are generated in their various forms and functional roles, he will know the general principles of cell signaling and gene regulation underlying their determination and diversity.
3. He will understand how the proliferation and selective death of neural progenitor cells, their mode of locomotion and targeted migration, the guided axonal growth and the establishment and pruning of synaptic connections contribute to the formation of neural circuits.
4. He will know how topographic maps of synaptic contacts are formed and how the functional properties of neuronal circuits appear, he will understand how patterns of neuronal connectivity are refined by the sensory and motor functions during later development.
5. He will know the peculiarities of the development of the cerebral cortex in humans.
6. Through various readings,he will be able to critically evaluate experiences and concepts in the literature.
Prerequisite knowledge and skills
Neuro430-1
Planned learning activities and teaching methods
10 2h lectures
Mode of delivery (face to face, distance learning, hybrid learning)
face-to-face
Organisational adjustments related to the current health context
Recommended or required readings
Updated versions of each chapter are available in pdf format on MyULg at the time of teaching
the books "Building Brains" by David J. Price et al. published by Wiley-Blackwell and "Development of the Nervous System" by DAn H. Sanes et al. may be worthwhile but definitely not mandatory readings.
Assessment methods and criteria
Below you will find information on the evaluation methods planned for in-person and remote exams as well as those planned for hybrid sessions. Depending on how the health crisis evolves, the chosen method will be communicated to you no later than one month before the start of the exam session.
oral examination. Each student prepares during 20 min three questions on the different chapters and then exposes his/her answers in front of the teacher.
Work placement(s)
Organizational remarks
see french version
Contacts
Pierre Leprince GIGA-Neuroscience Université de Liège CHU B36 B-4000 Liège Belgique Tél: 32 4 366 59 32 FAX: 32 4 366 59 12 pleprince@ulg.ac.be