Duration
20h Th, 40h Pr
Number of credits
| Bachelor in biology | 4 crédits |
Lecturer
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
In its first part, this course highlights the importance of equilibria in biochemistry, whereas the second part is an introduction of some fundamental aspects in enzyme kinetics. The first part is organized as follows: 1) Chemical equilibria; 2) Acid-base equilibria; 3) Complexation equilibria. As for the second part: 1. General properties of enzymes; 2. Steady-state kinetics; 3. Enzyme inhibition. More in depth analysis is covered in the Master course entitled "Enzymology".
Learning outcomes of the learning unit
The aim of this course is to familiarize students with equilibria in biochemistry and also with some fundamental aspects of enzymology.
Prerequisite knowledge and skills
Fundamentals of mathematics, chemistry and biochemistry.
Planned learning activities and teaching methods
The first part of the course describes some important aspects relating to equilibria in biochemistry. The second part consists in an introduction to enzyme catalysis. Witten exercises and practical courses are full part of the teaching.
Mode of delivery (face to face, distance learning, hybrid learning)
Most lectures are given using the blackboard and (hopefully) white chalk. Problem tutorials are organized in relation with some chapters (e.g. enzymology). Finally, 40 h of practical course are dedicated to protein purification and enzyme catalysis.
Organisational adjustments related to the current health context
Recommended or required readings
Lecture notes will be available as the course has progressed.
Some references:
N.C. Price, R.A. Dwek, R.G. Ratcliffe and M.R. Wormald, Principles and Problems in Physical Chemistry for Biochemists, Third Edition, Oxford University Press, 2001.
K.E. van Holde, W. C. Johnson, P.S. Ho, Principles of Physical Biochemistry, Prentice Hall, 1998.
A. Cornish-Bowden, M. Jamin, V. Saks: Cinétique enzymatique, Grenoble Sciences/EDP Sciences, 2005.
Assessment methods and criteria
Below you will find information on the evaluation methods planned for in-person and remote exams as well as those planned for hybrid sessions. Depending on how the health crisis evolves, the chosen method will be communicated to you no later than one month before the start of the exam session.
Written exam + practical courses
Work placement(s)
Non applicable
Organizational remarks
Lectures will be organized according to the schedule known by the students. The professor will inform the students in advance of any possible modification to this
Contacts
André Matagne, PhD, Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be