Duration
15h Th, 10h SEM
Number of credits
| Master in chemistry (120 ECTS) | 3 crédits | |||
| Master in chemistry (60 ECTS) | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
This course is organized as follows: Chapter 1: General properties of enzymes. Chapter 2: Steady-state kinetics. Chapter 3: Enzyme inhibition. Chapter 4: Effect of pH, temperature, viscosity and other experimental factors. Chapter 5: Reactions of two substrates. Chapter 6: Transient-state kinetics. Chapter 7: Cooperativity and allosteric interactions. Chapter 8: Enzyme inactivators. Chapter 9: Enzyme cofactors. Chapter 10: Mechanism of chymotrypsin. Chapter 11: Basic catalytic principles. Chapter 12: Regulation of catalytic activity. In addition some lectures might be dedicated to specific topics. This year, a lecture on the formation of disulphide bonds in proteins will be given by professor J.-F. Collet, WELBIO and de Duve Institute, U.C.L.
Learning outcomes of the learning unit
The aim of the course is to make students familiar with enzyme mechanisms and fundamentals of enzyme kinetics.
Prerequisite knowledge and skills
Course on "Equilibriums in biochemistry and enzyme kinetics" (BAC Biology), which includes an introduction to enzyme catalysis (chapters 1-3; note that both theoretical and practical aspects are covered).
Planned learning activities and teaching methods
Most lectures are given using the blackboard and (hopefuly) white chalk. Problems tutorials are organized in relation with some chapters.
Mode of delivery (face to face, distance learning, hybrid learning)
Face-to-face only
Organisational adjustments related to the current health context
Recommended or required readings
Lecture notes will be available following the lectures.
Reference book: A. Cornish-Bowden, Fundamentals of enzyme kinetics, fourth edition, Wiley-Blackwell, 2012.
Assessment methods and criteria
Below you will find information on the evaluation methods planned for in-person and remote exams as well as those planned for hybrid sessions. Depending on how the health crisis evolves, the chosen method will be communicated to you no later than one month before the start of the exam session.
Written exam
Work placement(s)
Non applicable
Organizational remarks
Lectures will be organized according to the schedule known by the students. The professor will inform the students in advance of any possible modification to this
Contacts
André Matagne, PhD, Full Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Quartier Agora, Allée du 6 Août, 13, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be