Duration
40h Th, 40h Pr, 20h QA Sess.
Number of credits
| Bachelor in pharmacy | 10 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Several sessions will be devoted to general notions related to organic bonds, major reaction types, hydrophilicity and lipophilicity as well as pH impact on such parameters.
Major functional groups (i.e. hydrocarbons, halogenated derivatives, alcohols, amines, acetaldehydes and ketones, acids and derivatives) will be presented. Preparations, physical properties, pH impact on hydro-lipophilic properties and molecule stability, as well as chemical reactivity will be described.
The issue of aromatic compounds and their derivatives will be dealt with from similar angles (preparations, physical properties, chemical reactivity). Aromatic heterocycles will be studied as well.
Most important inorganic compounds used in pharmaceutical will be examined (solubility, interaction with pH, oxidative or reductive properties,...). Possible interations with organic compounds will be also detailed.
Learning outcomes of the learning unit
Knowing about the reactivity and/or stability of organic functions for instance considering chemical agents or pH variation.
Grasping the spatial structure of organic molecules.
Recognizing fragility points in more complex molecules.
Recognizing polar and apolar fragments in organic molecules or even assessing hydrophilic/lipophilic natures.
Knowing about the major synthesis routes of functional groups from the mechanistic angle so as to understand the synthesis of more complex drugs.
Knowing properties of major inorganic compounds used in pharmaceutical sciences and their interactions with organic compounds.
Prerequisite knowledge and skills
The name, symbol and structure of common atoms in organic chemistry (C, H, N, S, O, P, B...). The periodic charts of the elements. Major organic functions. Inorganic reagents and their chemical characteristics
Planned learning activities and teaching methods
Seminar regarding structure related physicochemical characteristics
Organic chemistry experiments with a view to applying major studied reactions. Compound isolation, purification and analysis.
Qualitative analysis of organic compound and determination of physicochemical characteristics
Qualitative analysis of inorganic compounds and determination of physicochemical characteristics
Mode of delivery (face-to-face ; distance-learning)
Theoretical course (Q3): 20 x 2h including some demonstrations to show physicochemical behaviors of organic compounds
Repetition sessions (Q3): 10 x 2h (the class will be divided)
Practicals (Q3): ten sessions (the class will be divided), Practical hall B36 +4
THE ATTENDANCE TO THE DEMONSTRATION AND PRACTICALS IS MANDATORY
Recommended or required readings
Books on Organic Chemistry (Arnaud, Clayden, Vollhardt) might be useful. The Merck Index is a source of chemical informations. These documents might be consulted in libraries.
A copy of PowerPoint presentations and written lecture notes are available
Assessment methods and criteria
A written evaluation will take place in early October on previous matters. Another evaluation related to aliphatic chemistry chapters is scheduled in November. The written examination on the course including matter of the practical works is scheduled in January. Important concepts will be defined and will be perfectly mastered.
At the beginning of each practical session, a short written examination is scheduled.
The final mark includes the results of the prerequisite evaluation (5%), the evaluation on aliphatic chemistry (25 %), the mean of practical works including evaluations (20 %) and the written examination (50 %). The marks of practicals and both evaluations will be only reported for the second time round of the current academic year.
There is no partial exempt for the second time round or if the matter must be started the year after.
Work placement(s)
Organizational remarks
Theoretical course, repetitions and demonstration. During these activities, the use of mobile phones, smartphones or related electronic devices is not permitted except during a break.
Practicals. The safety and security rules will be strictly respected. A laboratory coat (in cotton) and safety glasses are required during all experimental tasks.
For security reasons, the use of mobile phones, smartphones or related electronic devices is prohibited in the laboratory.
If the safety and security rules are not followed, the student will be sanctioned either on the results or excluded from the laboratory.
Examinations. The matter and rules for each evaluations will be defined and sent via MyULiege.
Absences. All absences for mandatory activities must be quickly justified. Otherwise, in accordance with Article 6 of the General Examination Regulations, an excessively high absenteeism rate may lead to the inability to present the examination.
Student assistant: this job is available for those interested by the teaching organic chemistry during practical sessions.
Research: after the second year of the formation, students interested by organic chemistry and drug design are welcome for research training under my supervision Application for Research Student position is also possible.
Medicinal chemistry training can be done during the last year of the formation.
Finally, PhD degree can be prepared in the research unit.
Contacts
Jean-François Liégeois Associate Professor F.R.S.-FNRS Research Director Department of Pharmacy Avenue Hippocrate, 15 (B36, CHU, Tour 4, room 5/43B) B-4000 Liège 1 Phone: 32 (0)4 366 43 77 Email: JF.Liegeois@uliege.be
Adaptation of teaching commitments following the COVID-19 pandemic for the May-June 2020 session
Teaching methods implemented : distance-learning
Assessment subjects
Assessment methods
Contacts
Adaptation of teaching commitments following the COVID-19 pandemic for the Aug-Sept 2020 session
Assessment subjects
The matter is the same than in January and will be precised in a document sent by MyULiege
Assessment methods
The written examination will be organized through the Lifesize platform. Each question will be completed one after another. The maximum duration of the evaluation except the time to transfer the answers will be 2 hours.
The answers will be sent as a photograph of the page to the staff by email (more detailed informations will be sent by MyULiege)
More detailled informations will be sent by MyULiege
Two training sessions for using the platform will be organized
Problems regarding the computer or the connection must be solved quickly. A department at the University might be contacted.
Contacts
Jean-François Liégeois
other informations see above