Duration
15h Th
Number of credits
| Doctoral training in sciences (BBMC) | 3 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
The numerous facets of the DNA damage response (DDR) are presented.
The following points are detailed
- nature of the DNA lesions induced by endogenous or exogenous stresses
- repair systems (photolyase, MGMT, BER, NER, MMR, single- and double-strand break repair).
- signaling cascades controlled by ATM and ATR kinases
- alternative splicing and DNA damage
- translesion polymerases
Learning outcomes of the learning unit
At the end of the semester, the student will have aa knowledge of the "DNA DAMAGE RESPONSE" signalling cascade which is necessary to maintian the genome stability.
The following points will be developped:
-the balance between pro and anti-survival signaling upon a genotoxic stress.
- the importance of DDR cascade to prevent cancer initiation and progression
- importance of the DDR cascade in genotoxic anticancer therapies (chemo- and radio- therapies).
Prerequisite knowledge and skills
accessible to PhD students
Planned learning activities and teaching methods
lecture
research articles presented by the student in the last sessions
Mode of delivery (face-to-face ; distance-learning)
face-to-face
Recommended or required readings
a copy of the slides is given at the beginning of each lecture
Assessment methods and criteria
each student will explain one article
Work placement(s)
Organizational remarks
Contacts
yvette.habraken@uliege.be