Duration
40h Th, 40h Pr, 20h QA Sess.
Number of credits
| Bachelor in pharmacy | 10 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Several sessions will be devoted to general notions related to organic bonds, major reaction types, hydrophilicity and lipophilicity as well as pH impact on such parameters.
Major functional groups (i.e. hydrocarbons, halogenated derivatives, alcohols, amines, acetaldehydes and ketones, acids and derivatives) will be presented. Preparations, physical properties, pH impact on hydro-lipophilic properties and molecule stability, as well as chemical reactivity will be described.
The issue of aromatic compounds and their derivatives will be dealt with from similar angles (preparations, physical properties, chemical reactivity). Aromatic heterocycles will be studied as well.
Most important inorganic compounds used in pharmaceutical will be examined (solubility, interaction with pH, oxidative or reductive properties,...). Possible interations with organic compounds will be also detailed.
Learning outcomes of the learning unit
Knowing about the reactivity and/or stability of organic functions for instance considering chemical agents or pH variation.
Grasping the spatial structure of organic molecules.
Recognizing fragility points in more complex molecules.
Recognizing polar and apolar fragments in organic molecules or even assessing hydrophilic/lipophilic natures.
Knowing about the major synthesis routes of functional groups from the mechanistic angle so as to understand the synthesis of more complex drugs.
Knowing properties of major inorganic compounds used in pharmaceutical sciences and their interactions with organic compounds.
Prerequisite knowledge and skills
The name, symbol and structure of common atoms in organic chemistry (C, H, N, S, O, P, B...).
The periodic charts of the elements.
Major organic functions.
Inorganic reagents and their physicochemical characteristics
Planned learning activities and teaching methods
Seminar regarding structure related physicochemical characteristics
Organic chemistry experiments with a view to applying major studied reactions. Compound isolation, purification and analysis.
Qualitative analysis of organic compound and determination of physicochemical characteristics
Qualitative analysis of inorganic compounds and determination of physicochemical characteristics
Mode of delivery (face-to-face ; distance-learning)
Theoretical course (Q3): 20 x 2h including some demonstrations
Repetition sessions (Q3): 10 x 2h (the class will be divided)
Practicals (Q3): ten sessions (the class will be divided), Practical hall B36 +4
THE ATTENDANCE TO THE DEMONSTRATION AND PRACTICALS IS MANDATORY
Recommended or required readings
Books on Organic Chemistry (Arnaud, Clayden, Vollhardt) might be useful. The Merck Index is a source of chemical informations. These documents might be consulted in libraries.
A copy of PowerPoint presentations and written lecture notes are available
Assessment methods and criteria
A written evaluation will take place in early October on previous matters. Another evaluation related to aliphatic chemistry chapters is scheduled in November. The written examination on the course including matter of the practical works is scheduled in January. Important concepts will be defined and will be perfectly mastered.
At the beginning of each practical session, a short written examination is scheduled.
Each evaluation must be succeeded with a mark of 10/20 including all evaluations during practical session. There is no partial exempt for the second time round or if the matter must be started the year after.
Work placement(s)
Organizational remarks
Theoretical course, repetition and demonstrations. During these activities, the use of mobile phones, smartphones or related electronic devices is not permitted except during a break.
Practicals. The safety and security rules will be strictly respected. A laboratory coat (in cotton) and safety glasses are required during all experimental tasks.
For security reasons, the use of mobile phones, smartphones or related electronic devices is prohibited in the laboratory.
If the safety and security rules are not followed, the student will be sanctioned either on the results or excluded from the laboratory.
Student assistant: this job is available for those interested by the teaching organic chemistry during practical sessions.
Research: after the second year of the formation, students interested by organic chemistry and drug design are welcome for research training under my supervision Application for Research Student position is also possible.
Medicinal chemistry training can be done during the last year of the formation.
Finally, PhD degree can be prepared in the research unit.
Contacts
Jean-François Liégeois Associate Professor F.R.S.-FNRS Research Director Department of Pharmacy Avenue Hippocrate, 15 (B36, CHU, Tour 4, room 5/43B) B-4000 Liège 1 Phone: 32 (0)4 366 43 77 Email: JF.Liegeois@uliege.be