Duration
25h Th
Number of credits
| Master in biochemistry and molecular and cell biology (120 ECTS) | 3 crédits |
Lecturer
Coordinator
Language(s) of instruction
French language
Organisation and examination
Teaching in the second semester
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
1: Basis of innate immunity
- Immune cells involved in pathogen recognition
- Expression and control of innate immune defense genes
- Transduction pathways and recognition motives
- Pathogen-associated molecular patterns
- Danger-associated molecular patterns
- Innate immune response receptors
- Inflammasome and sterile inflammation
- Virus recognition and viral interference
2: Inflammation
-Basis of the inflammatory reaction
- Consequences of the inflammatory reaction
- Out of control inflammatory reaction, chronicity
- Activation and modulation of the adaptative response: importance of the innate response
3: Principles of vaccine design
- Discovery of vaccination
- Modern approaches of vaccination
- Antigen processing
- Adjuvant concept
- Mucosal immunity
- Animal models for vaccination
4: Vaccinal antigen discovery and their engineering
- Bio-informatic, proteomic and phage display libraries
- Attenuated microbial vaccines
- Virus-like particles
- Recombinant vaccines
5: How to deliver a vaccine and how to evaluate its activity
- Trans-cutaneous immunisation and injection without needle
- Oral vaccines
- Biodegradable microparticles
- Advantages and drawbacks of multivalent vaccines
- Strategies and clinical follow-up
- Efficacy evaluation
- Safety
- Ethical concerns
Learning outcomes of the learning unit
Gain a preliminary view on the innate immune response and its importance in vaccination
Prerequisite knowledge and skills
Prerequisite in immunology, microbiology and molecular biology
Planned learning activities and teaching methods
Oral lessons. Depending on the number of registered students, other learning activities will be undertaken.
Of importance and if possible, lectures could be given by a scientist working in a vaccine company.
Mode of delivery (face-to-face ; distance-learning)
face-to-face
Recommended or required readings
Vaccinology: Principles and pratice by John Morrow et al.
Wiley press
Powerpoint presentations used for the lectures will be available on MyULg
Assessment methods and criteria
Oral presentation based on a publication related to a vaccination issue
Work placement(s)
Organizational remarks
None
Contacts
C. Sadzot
Laboratoire de Virologie et d'Immunologie,
GIGA B34 2° floor (Office at the 5° floor)
csadzot@ulg.ac.be
+32 4 366 24 45