GBIO0016-1

Duration

30h Th, 30h Pr

Number of credits

	Master in biomedical engineering (120 ECTS)	5 crédits
	Master in bio-informatics and modelling (120 ECTS)	5 crédits

Lecturer

Frank Delvigne, Philippe Jacques, Bernard Joris

Coordinator

N...

Language(s) of instruction

English language

Organisation and examination

Teaching in the second semester

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

The course will give an introduction to systems and synthetic biology.
The part "introduction to systems biology" covers the emerging properties of dynamical systems, such as robustness, performance, complexity and optimality.
The topics of the theoretical parts on synthetic biology are:

historical overview of synthetic biology
tools and approaches in synthetic biology
DNA sequencing and building of "elementary bricks"
mathematical modelling
measurements (microscopy, flow cytometry)
design of metabolic pathways
design of regulatory systems
security, social and ethical aspects

The theoretical part will be followed by a synthetic biology projet consisting of modelling and an implementation in E.coli.

Learning outcomes of the learning unit

At the end of this course, the student will master basic concepts of systems and synthetic biology. He or she will be able to build virtually as well as in E. coli simple synthetic systems.
This course is taught in English, with support material available in English.

Prerequisite knowledge and skills

none

Planned learning activities and teaching methods

The course is based on ex-cathedra lectures, and a laboratory project requiring the use of a computer for simulating biochemical reaction systems (Matlab or a software dedicated to simulating biological systems) as well as biological / biochemical manipulations.
This course is taught in English. Students may ask questions in French or English.

Mode of delivery (face-to-face ; distance-learning)

face-to-face

Assessment methods and criteria

Detailed individuel report (publication style) on the project (25%); oral examen (75%).
Participation in the project is a prerequisite for the final oral exam.

Work placement(s)

Organizational remarks

The course is organised in the second quadrimestre, at dates to be arranged.

Contacts

Franck DELVIGNE
Chimie et bio-industries / Bio-industries BG1 Bio-industries Passage des Déportés 2 5030 Gembloux Tel 081 622 311 F.Delvigne@ulg.ac.be

Bernard JORIS
Unité de Physiologie et Génétique bactériennes Centre d'Ingénierie des Protéines Institut de Chimie B6a Room 1.50b Tel 04 366 2954 bjoris@ulg.ac.be Secretary Fabienne Julémont Tel 04 366 3341

Introduction to systems and synthetic biology