Duration
15h Th, 25h Pr
Number of credits
| Master in bio-informatics and modelling (120 ECTS) | 5 crédits |
Lecturer
Language(s) of instruction
French language
Organisation and examination
Teaching in the first semester, review in January
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
Chapter 1: General properties of enzymes. Chapter 2: Steady-state kinetics. Chapter 3: Enzyme inhibition. Chapter 4: Effect of pH, temperature, viscosity and other experimental factors. Chapter 5: Reactions of two substrates. Chapter 6: Transient-state kinetics. Chapter 7: Cooperativity and allosteric interactions. Chapter 8: Enzyme inactivators. Chapter 9: Enzyme cofactors. Chapter 10: Mechanism of chymotrypsin. Chapter 11: Basic catalytic principles. Chapter 12: Regulation of catalytic activity.
Learning outcomes of the learning unit
The aim of the course is to make students familiar with both enzyme mechanisms and fundamentals of enzyme kinetics.
Prerequisite knowledge and skills
Courses on "Introduction to Enzymology" (BAC3 Biology) or "Biochemistry" (BAC3 Chemistry), which include an introduction to enzyme catalysis (chapters 1-3).
Planned learning activities and teaching methods
Most lectures are given using the blackboard and (hopefuly) white chalk.
Mode of delivery (face-to-face ; distance-learning)
face-to-face only
Recommended or required readings
Lecture notes will be available following the lectures.
Reference book: A. Cornish-Bowden, Fundamentals of enzyme kinetics, fourth edition, Wiley-Blackwell, 2012
Assessment methods and criteria
Oral exam
Work placement(s)
Non applicable
Organizational remarks
Same schedule as for BIOC0719-1, planned as decided by the professor and students
Contacts
Professor André Matagne, PhD, Enzymology and Protein Folding, Centre for Protein Engineering, Life Sciences Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be