2017-2018 / BIOC0716-1

Antibiotic resistance

Duration

25h Th, 25h Pr

Number of credits

 Master in biochemistry and molecular and cell biology (120 ECTS)5 crédits 

Lecturer

Moreno Galleni, Frédéric Kerff, Mohammed Terrak

Coordinator

Moreno Galleni

Language(s) of instruction

French language

Organisation and examination

Teaching in the first semester, review in January

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

During this thematic week, the different resistance mechanisms developed by bacteria against the different classes of clinically used antibiotics will be reviewed. A particular focus will be made on bacterial resistance towards aminoglycosides and inactivators of the enzymes involved in the biosynthesis of the bacterial cell wall. The different mechanisms of propagation of the resistance genes will be discussed and their potential biological cost analysed. The methods designed for the rapid detection of resistance mechanisms will be presented. Finally, the techniques recently developed for the design or high throughput screening of new antibiotics will be discussed.

Learning outcomes of the learning unit

Prerequisite knowledge and skills

Planned learning activities and teaching methods

Mode of delivery (face-to-face ; distance-learning)

25 hours of teaching during one week

languages: french/ english

Recommended or required readings

Power point presentation + overheads

Assessment methods and criteria

The evaluation will be based on the presentzation and discussion of an original published article.

Work placement(s)

Organizational remarks

Contacts

Prof. Galleni Moreno
Lab. Macromolécules Biologiques
Centre d'Ingénieire des Protéines
Local 2.10. Institut de Chimie B6a
Sart Tilman
mgalleni@ulg.ac.be
Tel 04/366 35 49
Fax 04/366 33 64



Prof. Joris Bernard
Centre d'Ingénieire des Protéines
B6a- Institut de Chimie - Sart Tilman
bjoris@ulg.ac.be



(bjoris@ulg.ac.be)