Proteins biochemistry

Duration

20h Th

Number of credits

Lecturer

Sabine Wislet

Language(s) of instruction

French language

Organisation and examination

Teaching in the second semester

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

This lecture part is dedicated to protein biochemistry. The chapters are :
1. Chemistry basis
2. Amino acids
3. Biosynthesis and structure of the proteins
4. Post-translational modifications
5. Structural characteristics 6. Enzymes 7. Protein functions 8. Purification and analyses 9. From protein to pathology 10. From protein to drugs

Learning outcomes of the learning unit

1. To be able to explain in details the structure of a protein the energetic and steric constraints that the protein faces when it folds to its native structure. 2. Being able to calculate various parameters of enzymatic reactions in Michaelis-Menten and non Michaelis-Menten reactions. 3. To known and being able to explain the various post-translational modifications undergone by proteins and the functional consequences of these changes. 4. To known and being able to explain the principles of the various methods of protein analysis.

Prerequisite knowledge and skills

General Biology, general cytology, general Biochemistry (partim I) and general physiology.

Planned learning activities and teaching methods

The theoretical lectures will be "ex-cathedra".

Mode of delivery (face-to-face ; distance-learning)

Lectures Program and schedule detailed in vade-mecum

Recommended or required readings

Students will have access to the pdf version of the syllabus, as well as, the presentation PPT

Assessment methods and criteria

Written examination on lectures and concepts developed during the courses will be organized according to the general program of the course.

Work placement(s)

Organizational remarks

Contacts

Lecturer : S Wislet, Assistant Professor
GIGA-Neuroscience, Tour de Pathologie 1, étage 0, Bureau 0/22 CHU 4000 Liège 1 (Sart Tilman). Tél. : 04/366.39.88,Fax : 04/366.59.12, Couriel : S.Wislet@ulg.ac.be
Secrétaire : L. Bourdoux Tél. : 04/366 59 50 Couriel : Larisia.Bourdoux@ulg.ac.be