SDOC0049-1 : Cellular responses to DNA damage

Study Programmes 2016-2017

SDOC0049-1

Cellular responses to DNA damage

Duration :

15h Th

Number of credits :

Doctoral training in sciences (BBMC)		3

Lecturer :

Yvette Habraken

Language(s) of instruction :

French language

Organisation and examination :

Teaching in the second semester

Units courses prerequisite and corequisite :

Prerequisite or corequisite units are presented within each program

Learning unit contents :

The numerous facets of the DNA damage response (DDR) are presented.
The following points are detailed
-nature of the DNA lesions induced by endogenous or exogenous stresses
-repair systems (photolyase, MGMT, BER, NER, MMR, single- and double-strand break repair).
-signaling cascades controlled by ATM and ATR kinases
-translesion polymerases

Learning outcomes of the learning unit :

At the end of the semester, the student will have aa knowledge of the "DNA DAMAGE RESPONSE" signalling cascade which is necessary to maintian the genome stability.
The following points will be developped:
-the balance between pro and anti-survival signaling upon a genotoxic stress.
- the importance of DDR cascade to prevent cancer initiation and progression
- importance of the DDR cascade in genotoxic anticancer therapies (chemo- and radio- therapies).

Prerequisite knowledge and skills :

accessible to PhD students

Planned learning activities and teaching methods :

lecture
research articles presented by the student in the last sessions

Mode of delivery (face-to-face ; distance-learning) :

face-to-face