Study Programmes 2016-2017
MICR1717-1  
General and clinical microbiology
Duration :
40h Th, 12h Pr
Number of credits :
Bachelor in pharmacy6
Lecturer :
Marie-Pierre Hayette, Pierrette Melin
Coordinator :
N...
Language(s) of instruction :
French language
Organisation and examination :
Teaching in the second semester
Units courses prerequisite and corequisite :
Prerequisite or corequisite units are presented within each program
Learning unit contents :
General microbiology (P.Melin and MP Hayette)
Contents:


  • Introduction (P. Melin)
  • Historical milestones (P. Melin)
  • The microbial world (P. Melin)
  • Bacteria, procaryotic cells (P. Melin)
  • Beneficial aspects of microbes (P. Melin)
  • Concepts of microbial diseases (P. Melin)
  • Control of microbial diseases: prevention and therapeutic approach (P. Melin)
  • Fungi (MP. Hayette)
  • Parasites (MP. Hayette)
 
Clinical microbiology (MP.Hayette)
This course is designed to provide you with basic knowledge of medical microbiology. It follows the general microbiology course you received last year giving basic knowledge on microorganisms and host-parasite relationships. You approach this year the main infectious diseases encountered in community. These will be addressed by anatomical site such as infections of the urogenital tract or respiratory tract because they are among the most commonly encountered.
This course will allow those who are destined to the pharmacy to best ensure their advisory role in prevention and treatment. For one who is destined to clinical biology, the course will provide the foundation reinforced during his training as a biologist. Finally for those who are destined for the industry or research, knowledge of medical microbiology provide a basis for the one who works in the sector of anti-infectives. For others, it will be a general microbiological knowledge.
Course Description
The course will focus on the epidemiology, clinical signs, diagnostic and therapeutic aspects. The anti-infective molecules will be detailed in connection with the resistance developed by microorganisms and major side effects.
Indeed, the course provides a link between anti-infectives and the target organism to better understand the interactions and the development of potential resistance.
NB. Infectious diseses will be addressed with the exception of viral infections that will be covered in the course of medical virology (Prof. N. Jacobs).

Contents
Diseases will be addressed by anatomical site. Be addressed: respiratory tract infections especially pneumonia of bacterial origin including tuberculosis; Urinary tract infections, as well as sexually transmitted diseases such as infections due to Chlamydia trachomatis, Neisseria gonorrhoeae and syphilis: Skin infections with emphasis on infections caused by S. aureus, superficial fungal infection (Candida, dermatophytes) and ectoparasites (lice, fleas); infections transmitted by arthropods like Lyme disease and malaria (imported tropical disease). Finally, the main mechanisms of resistance to antibiotics, antifungal and antiparasitic will include: types of mechanisms, mode of acquisition, prevalence.

Revision-Training
Continuously at the beginning of each course you will be interviewed by a quiz on the material covered previously. This will allow you to maintain your knowledge.
A review session is scheduled at the end of the course.
Learning outcomes of the learning unit :
Partim General microbiology
At the end of the course, the student will be able to:
  • identify the main microbial challenges on the earth
  • describe the importance of mortality associated to infectious diseases and the evolution/emergence of infectious diseases
  • summarize a few important milestones in the microbial history
  • describe the different groups of microorganisms and their characteristics
  • explain the important role and characteristics of biofilms
  • describe the main points of bacterial genetics and genome plasticity
  • report the principles of beneficials aspects of microbes
  • summarize the different symbiotic and pathogenic  relationships between microorganisms and human beings.
  • list the main bacterial virulence factors
  • describe the different modes of transmission of microbes to or between human beings
  • understand and summarize human defenses against microbial attack and prevention strategies (food security, access to drinking water, vaccines, sterilization - disinfection, antibiotics).
  • list the main groups of antibiotics, mode of action and resistance mechanisms
  • describe the principles of the main microbial methods used for clinical diagnostics
 
Partim clinical microbiology
At the end of the course you will have enriched your knowledge of the epidemiology of major infectious diseases encountered in the community, with focus on prevention and therapeutic. 
You will know the main techniques used in a microbiology laboratory for the diagnosis of infectious diseases.
Prerequisite knowledge and skills :
The prerequisite knowledges are
  • General biology
  • General Immunology.
The co-requesite knowledge is
  • General and medical virology (Pr N. Jacobs).
Planned learning activities and teaching methods :
General microbiology
The course is taught as lectures, supported by PowerPoint-type slides.
Students are invited to ask their questions after the lecture or by email.
Practical work sessions are compulsory.  They illustrate the theoretical course.  Biosecurity and hand hygiene are introduced at the first session
 
Clinical microbiology
The course will be presented in the form of lectures. Practical sessions are also organized. Tutorials are presented in the form of workshops that illustrate the lectures through demonstration of diagnostic tests, microscopical and macroscopical observations (bacterial and fungal cultures, observation of adult parasites), projection of videos. On the other hand, a video will be made available as a virtual tour of the medical microbiology laboratory.
Mode of delivery (face-to-face ; distance-learning) :
Face-to-face
Participation of two lecturers
  • P. Melin and MP Hayette for general microbiology
  • MP Hayette for clinical microbiology
Practical works sessions
  • coordinated by Julie Descy, pharmacist, specialist in clinical biology and microbiology, university hospital of Liege
  • attendance is compulsory
Slide sets and lab syllabus available online
Recommended or required readings :
Slide sets of theoretical lectures  as well as syllabus of pratical works, posted on the ULg website, which can be downloaded by the concerned students, are compulsory. The following books are good references related to the course:
  • MIMS' MEDICAL MICROBIOLOGY, Mims C. et al, 5th Ed.,2012, Elsevier
  • INTRODUCION A LA MICROBIOLOGIE, Tortora G.J. et al, 2nd Ed., 2012, ERPI, Editions du Renouveau Pédagogique Inc.
  • BROCK BIOLOGY OF MICROORGANISMS, MT Madigan et al, 14th Ed, 2014,Pearson
  • THE MICROBIAL CHALLENGE, Krasner R., 2002, Ed. ASM PRESS
  • MICROBIOLOGIE, Prescott, Willey JM et al, Traduction de la 8ème Ed,2013, Ed.De Boeck Université
  • INFECTIOLOGIE, Tome 3. 3ème édition. Collection Le moniteur internat. 2007
Site web recommandé




 
Assessment methods and criteria :
Written examinations for the theorical (June / September) (multiple choice questions, open questions with short answers). Written evaluation (multiple choice questions +/- open questions with short answers) for the practical works, organized after the last SEANCE of each group.  The evaluation is included for 10% in the notes obtained in the first session.
Work placement(s) :
Opportunity for a 3-month internship during the last year of master and production of a final thesis
Organizational remarks :
For practical works session
  • the coordinator is Julie Descy, pharmacist, specialist in clinical biology and microbiology, university hospital of Liege
  • Attendance is compulsory
  • Access is restricted only to students wearing a labcoat.
Contacts :
Clinical Microbiology department University hospital of Liège, B-23 Sart Tilman, 4000 LIEGE Belgium Secretary For any contact or appointment request, please address your demand to the secretary Mrs MC Lhôte
Professors and lecturers Pierrette Melin
Marie-Pierre Hayette
  Training Julie Descy
Items online :
General mycology
These slides will be presented during the course
General parasitology (slides)
These slides will be presented during the course
General microbiology Slide set 2017 P.Melin
Slide set
General mycology
Syllabus
General parasitology
syllabus
Exercices
The syllabus of the practical work includes the methodologies used for the study of bacteria, yeasts, viruses. It describes the serological reactions and principles of molecular biology applied to microbiological diagnosis.
Exercices
The syllabus of the practical work includes the methodologies used fot the study of bacteria, yeasts, viruses. it describes the serological reactions and principles of molecular biology applied to microbiological diagnosis.