MICR0002-1 : Immunology and vaccinology

Study Programmes 2016-2017

MICR0002-1

Immunology and vaccinology

Duration :

25h Th

Number of credits :

Master in biochemistry and molecular and cell biology (120 ECTS)		3

Lecturer :

Catherine Sadzot

Coordinator :

Jacques Piette

Language(s) of instruction :

French language

Organisation and examination :

Teaching in the second semester

Units courses prerequisite and corequisite :

Prerequisite or corequisite units are presented within each program

Learning unit contents :

1: Basis of innate immunity - Immune cells involved in pathogen recognition - Expression and control of innate immune defense genes - Transduction pathways and recognition motives - Pathogen-associated molecular patterns - Danger-associated molecular patterns - Innate immune response receptors - Inflammasome and sterile inflammation - Virus recognition and viral interference
2: Inflammation -Basis of the inflammatory reaction - Consequences of the inflammatory reaction - Out of control inflammatory reaction, chronicity - Activation and modulation of the adaptative response: importance of the innate response
3: Principles of vaccine design - Discovery of vaccination - Modern approaches of vaccination - Antigen processing - Adjuvant concept - Mucosal immunity - Animal models for vaccination
4: Vaccinal antigen discovery and their engineering - Bio-informatic, proteomic and phage display libraries - Attenuated microbial vaccines - Virus-like particles - Recombinant vaccines
5: How to deliver a vaccine and how to evaluate its activity - Trans-cutaneous immunisation and injection without needle - Oral vaccines - Biodegradable microparticles - Advantages and drawbacks of multivalent vaccines - Strategies and clinical follow-up - Efficacy evaluation - Safety - Ethical concerns

Learning outcomes of the learning unit :

Gain a preliminary view on the innate immune response and its importance in vaccination

Prerequisite knowledge and skills :

Prerequisite in immunology, microbiology and molecular biology

Planned learning activities and teaching methods :

Oral lessons. Depending on the number of registered students, other learning activities will be undertaken.
Of importance and if possible, lectures could be given by a scientist working in a vaccine company.

Mode of delivery (face-to-face ; distance-learning) :

face-to-face