Study Programmes 2016-2017
MBIO0002-1  
Pharmaceutical Microbiology
Duration :
16h Th
Number of credits :
Master in pharmacy (120 ECTS)2
Lecturer :
Pierrette Melin
Language(s) of instruction :
French language
Organisation and examination :
Teaching in the first semester, review in January
Units courses prerequisite and corequisite :
Prerequisite or corequisite units are presented within each program
Learning unit contents :
Contents


  • Antibiotimicrobial agents
- Revision - Emergence of multi-resistant bacteria - Ecology of resistance - Role of the pharmacist and educational tools towards a better use of antibiotics


  • Quality assurance for drug production
- Introduction - Contaminations: risks, causes and outcomes - Control of the level of contamination     (Microorganisms, transmission; GMP and QA; systems of reference; testing methods; preservative systems; microbiological methods; Preservative efficacy testing; disinfectant efficacy testing.)


  • Sterilisation - disinfection
- Introduction - Microbial targets - Definitions and goals - Sterilization methods:          Physical procedures (dry and moist heat, air and liquid filtration, irradiation)         Gazeous sterilization (ethylene oxyde, formaldehyde, plasma H2O2)         Chemical agents  (peracetic acid)         Sterilization control and sterility assurance - Antiseptics and disinfectants


  • Vaccines
- Introduction - Vaccines strategies - types of vaccines - Conjugation - Adjuvants - Recommended vaccines in Belgium
Learning outcomes of the learning unit :
At the end of this course, students will be able to
  • list and give characteristics of the main antibiotics used at hospital or in ambulatory care.
  • provide useful recommendations and explanations for the best compliance to an antimicrobial treatment.
  • argue why all types of infections don't need to be treated with antibiotics.
  • explain the role of antibiotic pressure on emergence of resistance.
  • describe the impact of contaminations on pharmaceutical products.
  • decribe characteristics and sources of contaminating microbial agents.
  • summurize basis of GMP related to microbiological quality.
  • explain the principle and limits of sterility tests.
  • understand the requirements for production under appropriate controlled microbiological conditions.
  • summarize the main sterilization methods and their characteristics, to be used in industry, at hospital or in the dispensory.
  • discuss the indications and limits of the main antiseptics and disinfectants.
  • describe the different types of vaccines, their indications, side effects, target population.
  • explain the expected goals of glycoconjugation and used of adjuvants in vaccine technology.
  • list the compulsory vaccines in Belgium.
  • explain the goal of booster.
Prerequisite knowledge and skills :
Prerequisite or corequisite units are presented within each program.
Planned learning activities and teaching methods :
The course will be taught as lectures, supported by PowerPoint-type slides.
From time to time, short Quiz are proposed to attract students' attention and to check their knowledge before and/or after a teached chapter.
Students are invited to ask their questions after the lecture or by email.
Mode of delivery (face-to-face ; distance-learning) :
Face-to-face. Lectures are mainly ex-cathedra.
Recommended or required readings :
Slide sets of all lectures are available on the university website with  a "myULg" access. A non exhaustive list of text-books can also be useful but they are not necessary. 
  • Hugo&Russell's Pharmaceuticals microbiology, S.Denyer, N. Hodges, S. Gorman, B. Gilmore, 8th Ed. 2011, Wiley-Blackwell
  • Microbial Quality Assurance in Pharmaceuticals, Cosmetics, and Toiletries, R. Baird,  Sally F. Bloomfield, Taylor andFrancis, 1996
  • Vaccine design: Innovative Approaches and Novel Strategies, R Rappuoli et F Bagnoli, Caister Academic Press, 2011
  • Vaccinologie, J. Gaudelus, Doin editeurs, 2008
  • Medical microbiology, Mims C. et al, 5th Ed.,2012, Elsevier
  • Bactériologie médicale, F.Denis, MC. Ploy, C. Martin, E. Bingen, R. Quentin et al. 2ème Ed., 2011, Masson Paris
Assessment methods and criteria :
Written exam : questions with multiple choice and open questions.
Work placement(s) :
Student assistant: opportunities are given to students interested in teaching Microbiology. The work mainly consists of supervising laboratory workshop.
Internship opportunity during the last year of master (final thesis).
Organizational remarks :
Contacts :
Clinical microbiology Department University Hospital of Liège, B-23 Sart Tilman, 4000 LIEGE Belgium Secretary For any contact or to fix an appointment, please contact the secretary Mrs MC Lhote
Professor Pierrette Melin
Items online :
Pharmaceutical microbiology - Part I Microbiological quality of pharmaceutical products - 2016
Slide set including the introduction and the part I/IV, Microbiological quality of pharmaceutical products
Pharmaceutical microbiology - Part II Sterilization - Desinfection - 2016
slideset