Study Programmes 2015-2016
| BIOC9243-1 | ||||||||||||||
| Introduction to Enzymology | ||||||||||||||
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Duration :
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| 20h Th, 40h Pr | ||||||||||||||
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Number of credits :
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Lecturer :
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| Moreno Galleni, André Matagne | ||||||||||||||
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Coordinator :
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| André Matagne | ||||||||||||||
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Language(s) of instruction :
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| French language | ||||||||||||||
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Organisation and examination :
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| Teaching in the second semester | ||||||||||||||
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Units courses prerequisite and corequisite :
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| Prerequisite or corequisite units are presented within each program | ||||||||||||||
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Course contents :
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| In its first part, this course highlights the importance of equilibria in biochemistry, whereas the second partis an introduction of some fundamental aspects in enzyme kinetics. The first part is organized as follows: 1) Chemical equilibria; 2) Acid-base equilibria; 3) Complexation equilibria. As for the second part: 1. General properties of enzymes; 2. Steady-state kinetics; 3. Enzyme inhibition. More in depth analysis is part of the Master course entitled "Functional properties of biological macromolecules". | ||||||||||||||
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Learning outcomes of the course :
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| The aim of this course is to familiarize students with equilibria in biochemistry and also with some fundamental aspects of enzymology. | ||||||||||||||
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Prerequisite knowledge and skills :
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| Fundamentals of mathematics, chemistry and biochemistry. | ||||||||||||||
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Planned learning activities and teaching methods :
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| The first part of the course describes some important aspects relating to equilibria in biochemistry. The second part consists in an introduction to enzyme catalysis. Witten exercises and practical courses are full part of the teaching. | ||||||||||||||
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Mode of delivery (face-to-face ; distance-learning) :
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| Most lectures are given using the blackboard and (hopefully) white chalk. Problem tutorials are organized in relation with some chapters (e.g. enzymology). Finally, 40 h of practical course are dedicated to protein purification and enzyme catalysis. | ||||||||||||||
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Recommended or required readings :
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| Lecture notes will be available at the end of the course.
Some references: N.C. Price, R.A. Dwek, R.G. Ratcliffe and M.R. Wormald, Principles and Problems in Physical Chemistry for Biochemists, Third Edition, Oxford University Press, 2001. K.E. van Holde, W. C. Johnson, P.S. Ho, Principles of Physical Biochemistry, Prentice Hall, 1998. A. Cornish-Bowden, M. Jamin, V. Saks: Cinétique enzymatique, Grenoble Sciences/EDP Sciences, 2005. |
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Assessment methods and criteria :
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| Written exam + practical courses | ||||||||||||||
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Work placement(s) :
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Organizational remarks :
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| Lectures will be organized according to the schedule known by the students. The professor will inform the students in advance of any possible modification to this | ||||||||||||||
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Contacts :
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| André Matagne, PhD, Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be | ||||||||||||||