Study Programmes 2015-2016
BIOC0719-2  
Enzymology
Duration :
15h Th, 25h Pr
Number of credits :
Master in bio-informatics and modelling (120 ECTS)5
Lecturer :
André Matagne
Language(s) of instruction :
French language
Organisation and examination :
Teaching in the first semester, review in January
Units courses prerequisite and corequisite :
Prerequisite or corequisite units are presented within each program
Course contents :
Chapter 1: General properties of enzymes. Chapter 2: Steady-state kinetics. Chapter 3: Enzyme inhibition. Chapter 4: Effect of pH, temperature, viscosity and other experimental factors. Chapter 5: Reactions of two substrates. Chapter 6: Transient-state kinetics. Chapter 7: Cooperativity and allosteric interactions. Chapter 8: Enzyme inactivators. Chapter 9: Enzyme cofactors. Chapter 10: Mechanism of chymotrypsin. Chapter 11: Basic catalytic principles. Chapter 12: Regulation of catalytic activity.
Learning outcomes of the course :
The aim of the course is to make students familiar with both enzyme mechanisms and fundamentals of enzyme kinetics.
Prerequisite knowledge and skills :
Courses on "Chemistry of biological macromolecules" (BAC3 Biology) or "Biochemistry" (BAC3 Chemistry), which include an introduction to enzyme catalysis (chapters 1-3).
Planned learning activities and teaching methods :
Most lectures are given using the blackboard and (hopefuly) white chalk.
Mode of delivery (face-to-face ; distance-learning) :
face-to-face only
Recommended or required readings :
Lecture notes will be available following the lectures.
Reference book: A. Cornish-Bowden, Fundamentals of enzyme kinetics, fourth edition, Wiley-Blackwell, 2012
Assessment methods and criteria :
Oral exam
Work placement(s) :
Organizational remarks :
Same schedule as for BIOC0719-1, planned as decided by the professor and students
Contacts :
Professor André Matagne, PhD, Enzymology and Protein Folding, Centre for Protein Engineering, Life Sciences Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be