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| SDOC0049-1 | Cellular responses to DNA damage
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| Duration : | 15h Th |
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| Number of credits : |
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| Lecturer : | Yvette Habraken |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the second semester |
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Course contents :
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| The numerous facets of the DNA damage response (DDR) are presented.
The following points are detailed
-nature of the DNA lesions induced by endogenous or exogenous stresses
-repair systems (photolyase, MGMT, BER, NER, MMR, single- and double-strand break repair).
-signaling cascades controlled by ATM and ATR kinases
-translesion polymerases |
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Learning outcomes of the course :
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| At the end of the semester, the student will have aa knowledge of the "DNA DAMAGE RESPONSE" signalling cascade which is necessary to maintian the genome stability.
The following points will be developped:
-the balance between pro and anti-survival signaling upon a genotoxic stress.
- the importance of DDR cascade to prevent cancer initiation and progression
- importance of the DDR cascade in genotoxic anticancer therapies (chemo- and radio- therapies). |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| accessible to PhD students |
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Planned learning activities and teaching methods :
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| lecture
research articles presented by the student in the last sessions |
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Mode of delivery (face-to-face ; distance-learning) :
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| face-to-face |
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Recommended or required readings :
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| a copy of the slides is given at the beginning of each lecture |
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Assessment methods and criteria :
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| each student will explain one article |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| yvette.habraken@ulg.ac.be |
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