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| NEUR0432-1 | Complement of neurobiology
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| Duration : | 20h Th, 10h Pr |
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| Number of credits : |
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| Lecturer : | Pierre Leprince |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the second semester |
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Course contents :
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| Second part of the course on cellular and molecular neurobiology
This course focuses on the cellular and molecular mechanisms involved in the development of the nervous system.
Ten chapters cover some of the most recently described aspects of the following steps of brain development:
- Neural and mesodermal induction
- Polarity and regionalization of the nervous system
- Neural stem cells
- Cellular determination
- Neuronogenesis
- Neuronal migration
- Trophicity and programmed cell death
- Axonogenesis and axonal guidance
- Innervation and synaptogenesis
- Synaptic elimination |
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Learning outcomes of the course :
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| At the end of this course the student will master the following questions:
1. He will understand how the embryonic neuroepithelium is induced and then partitioned between future divisions of the nervous system, he will know how the plasticity of gene expression, mechanisms of intercellular signaling and of intrinsic differentiation of cells contribute to the polarization and the delineation of future parts of the brain, he will apprehend the evolutionary history of the nervous system through a comparative approach in invertebrates and vertebrates.
2. He will understand how cell populations are generated in their various forms and functional roles, he will know the principles of cell signaling and gene regulation underlying their determination and diversity.
3. He will understand how the proliferation and selective death of neural progenitor cells, their mode of locomotion and targeted migration, the guided axonal growth and the establishment and pruning of synaptic connections contribute to the formation of neural circuits.
4. He will know how topographic maps of synaptic contacts are formed and how the functional properties of neuronal circuits appear, he will understand how patterns of neuronal connectivity are refined by the sensory and motor functions during later development.
5. Through various readings,he will be able to critically evaluate experiences and concepts in the literature. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Neuro430-1 |
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Planned learning activities and teaching methods :
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| 10 2h lectures |
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Mode of delivery (face-to-face ; distance-learning) :
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| face-to-face |
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Recommended or required readings :
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| Updated versions of each chapter are available in pdf format on MyULg at the time of teaching
the recent book "Building Brains" by David J. Price et al. published by Wiley-Blackwell may be a worthwhile but definitely not mandatory reading. |
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Assessment methods and criteria :
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| oral examination |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Pierre Leprince
GIGA-Neuroscience
Université de Liège
CHU B36
B-4000 Liège
Belgique
Tél: 32 4 366 59 32
FAX: 32 4 366 59 12
pleprince@ulg.ac.be |
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