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| MICR0002-1 | Immunology and vaccinology
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| Duration : | 25h Th |
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| Number of credits : |
| Master in Biochemistry and Molecular and Cell Biology, Research Focus, 1st year | | 3 |
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| Master in Biochemistry and Molecular and Cell Biology, Teaching Focus, 1st year | | 3 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bio-industrie, 1st year | | 3 |
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| Master in Biochemistry and Molecular and Cell Biology, Professional Focus in
Industrial Biochemistry, 1st year | | 3 |
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| Master en biochimie et biologie moléculaire et cellulaire, à finalité spécialisée en bioinformatique et modélisation, 1st year | | 3 |
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| Lecturer : | Jacques Piette, Catherine Sadzot |
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| Coordinator : | Jacques Piette |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the second semester |
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Course contents :
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| Chapter 1: Basis of innate immunity (10h)
Immune cells involved in pathogen recognition
Expression and control of innate immune defense genes
Transduction pathways and recognition motives
Pathogen-associated molecular patterns
Danger-associated molecular patterns
Innate immune response receptors
Toll-like receptors. Their discovery in insect and plant. Signal transduction pathways in animal
Cytosolic receptors: NLR, RLR
Inflammasome and sterile inflammation
Virus recognition and viral interference
Chapter 2: Inflammation (5h)
Basis of the inflammatory reaction
Consequences of the inflammatory reaction
Out of control inflammatory reaction, chronicity
Activation and modulation of the adaptative response: importance of the innate response
Chapter 3: Principles of vaccine design (5h)
Discovery of vaccination
Modern approaches of vaccination
Antigen processing
Adjuvant concept
Mucosal immunity
Animal models for vaccination
Chapter 4: Vaccinal antigen discovery and their engineering (3h)
Bio-informatic, proteomic and phage display libraries
Attenuated microbial vaccines
Virus-like particles
Recombinant vaccines
Chapter 5: How to deliver a vaccine and how to evaluate its activity (2h)
Trans-cutaneous immunisation and injection without needle
Oral vaccines
Biodegradable microparticles
Advantages and drawbacks of multivalent vaccines
Strategies and clinical follow-up
Efficacy evaluation
Safety
Ethical concerns |
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Learning outcomes of the course :
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| Gain a preliminary view on the innate immune response and its importance in vaccination |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Prerequisite in immunology, microbiology and molecular biology |
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Planned learning activities and teaching methods :
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| Oral lessons. Depending on the number of registered students, other learning activities will be undertaken.
Of importance and if possible, lectures could be given by a scientist working in a vaccine company. |
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Mode of delivery (face-to-face ; distance-learning) :
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| face-to-face |
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Recommended or required readings :
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| Vaccinology: Principles and pratice by John Morrow et al.
Wiley press |
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Assessment methods and criteria :
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| Oral examination |
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Work placement(s) :
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Organizational remarks :
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| None |
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Contacts :
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| J. Piette & C. Sadzot |
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