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| INFO0430-2 | Notions of bioinformatics
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| Duration : | 10h Th, 10h Pr |
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| Number of credits : |
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| Lecturer : | Olivier Peulen |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the first semester, review in January |
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Course contents :
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| The course will define and describe stakes of bioinformatics in XXIst century. Genomic and proteomic databases will be described. Retrieving of sequences in databases will be explained. Some algorithms of exon detection will be exposed. Notions of distance, similarity and homology will be introduced. Dot plots, alignment methods, consensus sequence detection and PCR primer design will be introduced. A chapter will be dedicated to phylogenetics.
Content :
- Introduction and scenario
- Informatic tool
- Cell constituants and bioinformatics
- Dot-plots
- Homology, distance, similarity
- Pair alignment
- Substitution Matrix
- Multiple alignment
- FASTA
- BLAST
- Molecular phylogeny
- Genomics and exon detection
- Structure prediction
- Databases
- Genbank
- Practical lessons |
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Learning outcomes of the course :
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| Students might be able to use basic bioinformatic softwares available on WWW and to understand mechanisms involved in this softwares. This understanding might allow them to determine limitations of each procedure. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Basic knowledge of web.
Statistic and Probability |
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Planned learning activities and teaching methods :
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| Practical use of bioinformatic web ressources : Genbank, Swissprot, PDB, BLAST, primer3, ... |
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Mode of delivery (face-to-face ; distance-learning) :
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| Lessons take place during the first master, 2 h/week for 5 weeks. |
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Recommended or required readings :
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| Syllabus (~150 pages) and a CD with powerpoint files are available. Syllabus can be obtained on My ULg website. Powerpoint files can be obtained on My ULg website. |
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Assessment methods and criteria :
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| Oral examination |
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Work placement(s) :
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Organizational remarks :
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| Textbook :
1) Fundamental concepts of bioinformatics, Dan E. Krane & Michael L. Raymer, Benjamin Cummings Editor (2003)
2) Introduction to Bioinformatics, Arthur M. Lesk, Oxford University Press (2002) |
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Contacts :
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| Olivier Peulen
Metastasis Research Laboratory
CHU - Tour de Pathologie B23
Te: 04/366.37.92
E-mail: Olivier.Peulen@ulg.ac.be |
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