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| CHIM0678-1 | Biochemistry
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| Duration : | 30h Th |
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| Number of credits : |
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| Lecturer : | André Matagne |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the first semester, review in January |
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Course contents :
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| Chapter I. Protein structure and function: I.1. Amino acids; I.2. Peptide bond; I.3. Non-covalent interactions; I.4. Secondary structure; I.5. Tertiary and quaternary structures; I.6. Fibrous and globular proteins; I.7. Protein folding. Chapter II. Basic concepts in Enzymology: II.1. General properties of enzymes; II.2. Enzyme kinetics : steady-state - independent binding sites; II.3. Enzyme inhibition; II.4. Catalytic strategies. Chapter III. Biological membranes: III.1. Membrane lipids; III.2. Lipid bilayers; III.3. Membrane proteins; III.4. Structure of membrane proteins. Chapter IV. Nucleic acid and the flow of genetic information: IV.1. Nucleotides; IV.2. DNA structure; IV.3. DNA replication; IV.4. Gene expression. Chapter V. Metabolism: V.1. Glycolysis and gluconeogenesis; V.2. Krebs cycle; V.3 Oxidative phosphorylation; V.4. Photosynthesis |
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Learning outcomes of the course :
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| The aim of these lectures is to teach students with fundamentals in biochemistry, i.e. 1) the structure of biological (macro)molecules, namely proteins, nucleic acids, lipids and carbohydrates; 2) their organization and function; 3) their metabolism. Emphasis will be given on the application of basic chemical principles in the life sciences. |
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Prerequisites and co-requisites/ Recommended optional programme components :
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Planned learning activities and teaching methods :
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| 30 hours of lectures, given with the help of powerpoint presentations, blackboard and white chalk |
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Mode of delivery (face-to-face ; distance-learning) :
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| Face-to-face only |
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Recommended or required readings :
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| Lecture notes will be available following the lectures
Reference book:
Jeremy M. Berg, John L. Tymoczko and Lubert Stryer (2012) Biochemistry, 7th edition, W.H. Freeman and Co., New York. |
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Assessment methods and criteria :
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| A mixed oral and written exam will be organized. The oral part is for ca. 30 min, with maximum 15 min of preparation and thus minimum15 min of discussion. For the written part (30 min) the student will have to solve a problem, as discussed for the lectures |
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Work placement(s) :
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Organizational remarks :
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| Lectures will be organized following the schedule known by the students. The professor will inform the students in advance of any possible modification to this |
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Contacts :
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| André Matagne, PhD, Professor, Enzymology and Protein Folding, Centre for Protein Engineering, Life Science Department, Institut de Chimie B6c (room 3/1), Allée de la Chimie, 3, University of Liège, B4000 Liège (Sart-Tilman), Tel.: +32 (0)4 3663419, Fax: +32 (0)4 3663396, Email: amatagne@ulg.ac.be |
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