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| BIOC0724-2 | Chemistry of biological macromolecules, Including thermodynamics of biological systems
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| Duration : | 70h Th, 40h Pr |
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| Number of credits : |
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| Lecturer : | Moreno Galleni, André Matagne |
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| Coordinator : | Moreno Galleni |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| All year long |
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Course contents :
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| 1) Chemical properties of amino acids and of the polypeptide chain
1.1 Nature of the polypeptide chain
1.2 Amino acids
1.3 Detection of aminoacids, peptides and proteins
1.4 Determination of the protein size
1.5 Determination of the aminoacid sequence
1.6 Chemical synthesis of peptides
1.7 Non ribosomal synthesis of peptides
1.8 Post transcription modification of the polypeptide chain
2) Mechanism of protein localization in prokaryotes and eukaryotes
3) Interactions affecting the properties of proteins
3.1 Nature of non covalent interactions
3.2 Intramolecular interactions
4) Conformational properties of proteins
4.1 Secondary and ternary structures of proteins
4.2 Spectroscopic properties od proteins in solution
5) Biophysical properties of soluble and membranar properties
6) Protein-ligand interactions
7) Introduction to enzyme catalysis 7.1. General properties of enzymes 7.2 Steady-state kinetics 7.3. Enzyme inhibition |
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Learning outcomes of the course :
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| The first part of the course will be devoted to the structural and chemical properties of proteins. The second part consists in an introduction to enzyme catalysis |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| Lectures in genral biochemistry
Thermodynamic and classical physic
Organic chemistry |
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Planned learning activities and teaching methods :
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| Most lectures are given using the blackboard and (hopefuly) white chalk. Problem tutorials are organized in relation with some chapters (e.g. enzymology). Finally, 40 h of practical course, dedicated to protein purification and enzyme catalysis |
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Mode of delivery (face-to-face ; distance-learning) :
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| Face-to-face only |
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Recommended or required readings :
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| Syllabus + power point presentations |
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Assessment methods and criteria :
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| Practical courses + Written + oral examination
A minimal note of 8/20 will be requested for the two parts of the course |
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Work placement(s) :
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Organizational remarks :
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| Lectures will be organized following the schedule known by the students. The professor will inform the students in advance of any possible modification to this |
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Contacts :
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| Galleni Moreno, Local 3/7, Institut de Chimie , B6. Sart Tilman
Phone: 04/3663549 - Fax:04/3663364 - Email:mgalleni@ulg.ac.be
André Matagne, room 3/1, Chemistry building, B6c.
email: amatagne@ulg.ac.be |
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