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| Version 2011-2012 |
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| SDOC0049-1 | Cellular responses to DNA damage
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| Duration : | 15h Th |
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| Number of credits : |
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| Lecturer : | Yvette Habraken |
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Language(s) of instruction :
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| French language |
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Course contents :
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| The numerous facets of the DNA damage response (DDR) are presented.
The following points are detailed
-nature of the DNA lesions induced by endogenous or exogenous stresses
-repair systems (photolyase, MGMT, BER, NER, MMR, single- and double-strand break repair).
-signaling cascades controlled by ATM and ATR kinases
-translesion polymerases |
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Learning outcomes of the course :
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| The objectives of this course are to give the student a overview of the DDR in order to understand its importance in many cellular process.
Such as:
-the balance between life and death signals upon a genotoxic stress situation.
- the importance of DDR to prevent cancer developpement
- importance of the DDR in genotoxic cancer therapies |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| accessible to PhD students |
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Planned learning activities and teaching methods :
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| lecture
research articles presented by the student in the last sessions |
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Mode of delivery (face-to-face ; distance-learning) :
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| face-to-face |
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Recommended or required readings :
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| a copy of the slides is given at the end of the lecture |
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Assessment methods and criteria :
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| each student will explain one article |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| yvette.habraken@ulg.ac.be |
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