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| ANIM0003-1 | Immunology and immunochemistry
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| Duration : | 12h Th, 12h Pr |
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| Number of credits : |
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| Lecturer : | Daniel Portetelle |
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Language(s) of instruction :
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| French language |
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Organisation and examination :
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| Teaching in the second semester |
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Course contents :
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| . Overview of the immune system: historical perspective, innate immunity, acquired immunity
. Cells and organs of the immune system: hematopoiesis, CD antigens, cells and organs, antigen-presenting cells, dendritic cells, leucocytes migration and homing;
. Generation of B-cell and T-cell responses:
- antigens;
- immunoglobulins: structure and function;
- antigen-antibody interactions; principles and applications;
- organization and expression of immunoglobulin genes; antibody engeneering;
- B-cell maturation activation and differentiation;
- major histocompatibility complexes;
- antigen processing and presentation;
- T-cell receptor, T-cell maturation, activation and differentiation;
- Immune effector mechanisms:
- cytokines;
. Cell-mediated and humoral effector responses; regulation of the immune effector response
. Other aspects of immunity (overview):
immunodeficiency, tolerance, autoimmunity, hypersensitive reactions, inflammations, external factors, vaccinology (for more details, see ANIM0009-A-Immunobiology)
. Practical works:
productions of antibodies, precipitation reactions, agglutination reactions, the complement system and its applications, radioimmunoassay, enzyme-linked immunosorbent assay, survey of other techniques. |
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Learning outcomes of the course :
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| Acquisition of the molecular and cellular bases of immunology.
Supply of requisite informations on mechanisms and main current and prospective applications.
After completing the course the student is expected to
- understand the mechanism of the immune system of the being alive
- integrate the immunochemical approach in detection systems of molecules of some importance |
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Prerequisites and co-requisites/ Recommended optional programme components :
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| BIOL2015 - Molecular biology
BIOL2011 - Comparative animal anatomy and physiology |
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Planned learning activities and teaching methods :
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Mode of delivery (face-to-face ; distance-learning) :
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| Lectures : 12h
Practical Works : 12h |
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Recommended or required readings :
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| Kuby Immunology (Kindt, Osborne and Goldsby), 6°ed, 2007, W.H. Freeman, New York, 574 pages
French translation of the 4th ed., DUNOD, Paris, 2008, 704 pages.
Immunologie (Revillard, ed), 4°ed, 2001, De Boeck Université, Bruxelles, 600 pages
Text notes. |
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Assessment methods and criteria :
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| Written examination (100%) |
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Work placement(s) :
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Organizational remarks :
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Contacts :
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| Portetelle, Daniel (Professeur ordinaire - Chef de service)
Biologie animale et microbienne
081 62 23 54
daniel.portetelle@ulg.ac.be |
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