 | |
| PHYL0520-1 | General physiology
 |
|
| Duration : | 25h Th, 10h Pr |
|
| Credits/ECTS : |
|
|
| Holder(s) : | Bernard Rogister |
|
| Language : | French language |
|
| Course contents : | General Physiology is the science studying the regulation of the environment at the cellular level. This regulation aims to keep constant interior medium (homeostasis). These properties or mechanisms concern general properties of living being as action potential, synaptic transmission, hormonal regulation, the interaction ligand-receptor,.... . At the conceptual level, homeostasis implies: 1) the detection of a modification of environment by one or several sensor systems; 2) the transfer of the information from the sensor to an integrating centre; 3) a direct or an indirect appropriate response. Such an approach stresses the importance of the physical borders limiting the controlled environment. It is thus logical that most both detection (receptor) and effectors (secretion, ionic flow, ...) mechanisms lie at the plasma membrane.
List of the chapters :
1. Homeostasis and Cell Physiology
2. Diffusion and permeability.
3. Osmotic pressure and water movements.
4. Electric consequences of ionic gradients.
5. Ion channels
6. Passive electric properties of the membranes.
7. Generation and propagation of action potential
8. Diversity of ion channels
9. Energy of the electrochemical potential and mechanisms of transport.
10. Passive transport of diluted molecules.
11. Active transport.
12. Ligand-receptor interactions and second messengers. |
|
| Course objective : | 1. The general goal of this lecture is to stimulate the students to be familiar with regulation principles which is prevailing in life: to each accelerator, a brake corresponds. This supposes a very important (quantitatively and functionally) inter and intracellular communication.
2. To stimulate the integration of already acquired knowledge.
3. To stimulate the questioning of students. |
|
| Prerequisites : | Biochemistry, Biology, cytology and chemistry |
|
| Workshops : | Practical work will be organized as seminars:
1) The cell-free reconstituion of vesicle transport, James Rothman
2) The discovery of protein kinase C, Yasutomi Nishizuka
3) Determination of the full size of the action potential, Andrew Fielding Huxley.
4) Long term potentiation, Tim Bliss and Terje Lomo. |
|
| Organization : | Lectures
program and schedule detailed in vade-mecum
Practical Work/Seminars
program and schedule detailed in vade-mecum |
|
| Written notes : | Notes were written during the academic year 2006-2007. These will be corrected and improved during the academic year 2007-2008. The students will have the access to the computer files of notes and of the illustrations of the lectures. Moreover, the address and the access to several Internet websites specialized in this field will be given to the students. The examination relates on the theoretical lectures and on several key questions developed during seminars. |
|
| Assessment : | Written examination with open questions on the lectures is organized according to the general program of the studies. |
|
| Contacts : | Lecturer : Professeur B. Rogister,
Centre de Neurobiologie Cellulaire et Moléculaire, CNCM, Tour de Pathologie 2, étage +1, CHU 4000 Liège 1 (Sart Tilman).
Tél. : 04/366.59.17, Fax : 04/366.59.12, e-mail : Bernard.Rogister@ulg.ac.be.
Secretary : L. Bourdoux (04/366 59 50 or Larisia.Bourdoux@ulg.ac.be ) |
|
|
| |
