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| BIOC0718-2 | Structure-function of biomolecules
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| Duration : | 15h Th, 25h Pr |
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| Credits/ECTS : |
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| Holder(s) : | Mireille Dumoulin |
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| Language : | French language |
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| Course contents : | 1. Basis of protein folding and major techniques used to investigate protein folding in vitro
2. In vivo protein folding: Main techniques used to investigate protein folding in vivo and roles of chaperones
3. Degradation of misfolded proteins (proteosome)
4-5. Protein misfolding and diseases: i)Diseases associated with the loss of active protein; ii) Diseases associated with protein aggregation (amyloid disorders, non amyloid aggregation disorders)
6. Functional amyloids: i)Amyloids as functional coats for microorganisms; ii) Amyloids as orchester of the biosynthesis of melanin in mamalian tissues; iii) Prions: proteins as genes and infectious diseases; iii) Amyloid fibrils as nanomaterial
7. Functional glycoproteins, roles in biology. Structural glycoproteins, roles in extracellular matrix
8. Nanobodies: structure, properties and therapeutic applications
9. Toxin-antitoxin pairs in bacteria: killers or stress regulators?
10. Protein allostery, signal transmission and dynamics |
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| Course objective : | An approach to the thermodynamic and kinetic properties of biological macromolecules and of the techniques utilised in this type of studies. |
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| Prerequisites : | General, physical and organic chemistry. General biochemistry. Chemical thermodynamics. Structure of biological macromolecules. |
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| Organization : | Ten 90-min theoretical lectures |
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| Written notes : | Available |
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| Assessment : | Written exam. |
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| Contacts : | Dr Mireille Dumoulin
Institut de Chimie, Bât. B6a, 1er étage, local 1/50B, 4000 Liège 1 (Sart Tilman)
Tel.: 04/366.3546
e-mail : mdumoulin@ulg.ac.be |
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