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| BIOC0718-2 | Relations structure-fonction dans les biomolécules
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| Durée : | 15h Th, 25h Pr |
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| Crédits/ECTS : |
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| Titulaire(s) : | Mireille Dumoulin |
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| Langue : | Langue française |
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| Aperçu général : | 1. Basis of protein folding and major techniques used to investigate protein folding in vitro
2. In vivo protein folding: Main techniques used to investigate protein folding in vivo and roles of chaperones
3. Degradation of misfolded proteins (proteosome)
4-5. Protein misfolding and diseases: i)Diseases associated with the loss of active protein; ii) Diseases associated with protein aggregation (amyloid disorders, non amyloid aggregation disorders)
6. Functional amyloids: i)Amyloids as functional coats for microorganisms; ii) Amyloids as orchester of the biosynthesis of melanin in mamalian tissues; iii) Prions: proteins as genes and infectious diseases; iii) Amyloid fibrils as nanomaterial
7. Functional glycoproteins, roles in biology. Structural glycoproteins, roles in extracellular matrix
8. Nanobodies: structure, properties and therapeutic applications
9. Toxin-antitoxin pairs in bacteria: killers or stress regulators?
10. Protein allostery, signal transmission and dynamics |
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| Objectif du cours : | Donner une approche de l'étude des propriétés thermodynamiques et cinétiques des macromolécules biologiques et des méthodes qui la permettent. |
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| Pré-requis : | Chimie générale - Biochimie générale - Thermodynamique - Structure des macromolécules. |
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| Organisation : | 10 séances de cours de 90 minutes. |
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| Notes de cours : | Notes de cours disponibles. |
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| Evaluation : | Examen écrit. |
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| Contacts : | Dr Mireille Dumoulin
Institut de Chimie, Bât. B6a, 1er étage, local 1/50B, 4000 Liège 1 (Sart Tilman)
Tél.: 04/366.3546
e-mail : mdumoulin@ulg.ac.be |
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