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| VETE0088-2 | Embryology of pets | ||||||||
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| Duration : | 28h Th, 6h Pr | ||||||||
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| Holder(s) : | Luc Grobet | ||||||||
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| Course contents : | The embryology of domestic animals course describes the embryo development from its conception on until organogenesis. Particular attention is paid to particularities of domestic mammals and birds. Transgenesis techniques as tools for developmental biology studies are described as part of real research experiments. | ||||||||
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| Course objective : | The lectures proposed here aim at allowing students to learn about embryonic development and to get insight into some aspects of modern developmental biology. 1) Descriptive embryology. The embryonic development from fertilization on until birth is described here. The most common species of domestic mammals and birds are considered, and interspecies differences are also pointed out. Relevant relationships with anatomical, histological and physiological data are made. A) Gametogenesis Or gametes formation (ova and spermatozoa) from the primordial germ cell stage. B) Gametes and fertilization Or the different stages ending up with the zygote creation, which is the first embryonic stage. C) Cleavage stages Or the different division steps leading from the zygote (one cell) to the blastocyst stage. D) Gastrulation The embryo proper will undergo a clear cell differenciation in three primordial layers, from which all body tissues originate. E) Extraembryonic membranes and placentation The development of these extra-embryonic tissues allow feeding, oxygen supply and toxin elimination of the fetus. In mammals, the feto-maternal placental relationships are examined in respect with species particularities. F) Organogenesis Or development of the organs: we examine: - Heart and blood vessels - Nervous system - Urinary system - Reproductive organs - Digestive system and annexes - Respiratory system - Body cavities - Skeleton and joints formation - Muscles development - Skin and annexes 2) Modern biology of development and associated techniques. The most commonly used techniques for developmental biology studies are described. Their potential use as new biotechnological tool in applications such as farm animal improvement, disease resistance, therapeutic proteins production and xenograft supply are discussed based on concrete examples. A) Transgenesis Or integration by biotechnological means of (trans)genes in live organisms. B) Gene targeting Or precisely directed genome alterations in an organism. The most commonly reported use of gene targeting is gene inactivation by its partial or total elimination (Knock out). This technique can also generate minute insertion or deletions or site-directed integration of transgenes. C) Cloning Or genesis of a new organism without sexual reproduction, starting from a more or less differentiated somatic cell. | ||||||||
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| Prerequisites : | General biology knowledge | ||||||||
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| Workshops : | Analysis of a film about embryonic development and manipulation. Analysis of a topic related to develomental biology techniques. | ||||||||
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| Organization : | The lectures are given by the professor (L. Grobet) in two-hours periods. Powerpoint slides are used. | ||||||||
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| Written notes : | The lectures content are available on CD-Roms. Moreover hard copies are available through the "office des cours" press. | ||||||||
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| Assessment : | Evaluation by written exam, with multiple choice questionnaire and/or open questions. | ||||||||
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| Contacts : | Luc Grobet, 32 4 366 40 80, lgrobet@ulg.ac.be | ||||||||
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| Remarks : | http://www.ulg.ac.be/fmv/hist.htm | ||||||||
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ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
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