 |  |  |  |  |
| | |
||||
| CHIM0311-3 | Organic chemistry applied to pharmaceutical sciences | |||||
| ||||||
| Duration : | 45h Th, 20h Pr, 10h QA Sess. | |||||
| ||||||
| Credits/ECTS : |
| |||||
| ||||||
| Holder(s) : | Jean‑François Liégeois | |||||
| ||||||
| ||||||
| Course contents : | Several sessions will be devoted to general notions related to organic bonds, major reaction types, hydrophily and lipophily as well as pH impact on such parameters. Major functional groups (hydrocarbons, halogenated derivatives, alcohols, amines, acetaldehydes and ketones, acids and derivatives ) will be presented. Preparations, physical properties, pH impact on hydro-lipophilic properties and molecule stability, as well as chemical reactivity will be described. The issue of aromatic compounds and their derivatives will be dealt with from similar angles (preparations, physical properties, chemical reactivity). Aromatic heterocycles will be studied as well. | |||||
| ||||||
| Course objective : | Knowing about the reactivity and/or stability of organic functions for instance considering chemical agents or pH variation. Grasping the spatial structure of organic molecules. Recognizing fragility points in more complex molecules. Recognizing polar and apolar fragments in organic molecules or even assessing hydrophilic/lipophilic natures. Knowing about the major synthesis routes of functional groups from the mechanistic angle so as to understand the synthesis of more complex drugs. | |||||
| ||||||
| Prerequisites : | The structure of common atoms in organic chemistry (C, H, N, S, O, P, B...). Major organic functions. Basic mineral reagents physicochemical characteristics (NaOH, HCl, KMnO4...). | |||||
| ||||||
| Workshops : | Organic chemistry experiments with a view to applying major studied reactions. Compound isolation, purification and analysis. Extraction and characterization of natural compounds. Organic compound qualitative analysis and determination of physicochemical characteristics (solubility and extractability). | |||||
| ||||||
| Organization : | Theoretical course: Tuesdays and Thursdays (2nd term), 1:30pm to 3:30pm, A142 lecture theatre Repetition sessions: to be determined Practicals: five sessions, two groups, Thursday and Friday mornings from 8:30am to 12:30pm, Practical hall R/14 | |||||
| ||||||
| Written notes : | A copy of PowerPoint presentations and written lecture notes are available. | |||||
| ||||||
| Assessment : | Written and oral exams in the exam period. Some specific notions are essential in order to pass, get merits, distinctions and exemptions. Major elements will be emphasized during the course. | |||||
| ||||||
| Contacts : | Jean François Liégeois
Deputy Lecturer FNRS Senior Research Associate (Scientific Research National Fund) Département de Pharmacie Avenue de l'Hôpital, 1 (B36, CHU, Tour 4, niv. +5) B-4000 Liège 1 Phone: 32 (0)4 366 43 77 Fax: 32 (0)4 366 43 62 Email: JF.Liegeois@ulg.ac.be Supervision: Practical/Repetition sessions Cécile Kech Assistant lecturer Centre de Recherche du Cyclotron Allée du 6 août, 8 (B30) 4000 Liège 1 Phone: 32 (0)4 3662313 Email: ckech@ulg.ac.be | |||||
| ||||||
| Remarks : | Short tests on basic notions will be organized weekly and corrected in the next session. Miscellaneous: Details sheets. Students are asked to provide a details sheet with their names and surnames and a recent photograph before the beginning of the course. Details on prior chemistry education would be appreciated (secondary and university levels; theoretical AND practical education). Supervising student. A supervising student position will be offered to a student interested in teaching organic chemistry and synthesis. Tasks will consist in supervising practical sessions in the 1st year. Research. Students interested in the practical aspects of organic chemistry applied to drug synthesis can attend supervised laboratory training sessions outside of course and exam periods (ideally after the 2nd year). Practical research training (1 month) is also possible for last-year students. | |||||
| ||||||
ULg : Students and Studies Administration - Academic Affairs
Contact : Monique Marcourt, direction A.E.E.
Date of data : 27/02/2006
Developed by SEGI