Duration
18h Th, 2h Pr, 30h AUTR
Number of credits
| Master in biomedicine (120 ECTS) | 5 crédits |
Lecturer
Laurence Delacroix, Rachelle Franzen, Gaëtan Garraux, Vincent Seutin
Language(s) of instruction
English language
Organisation and examination
Teaching in the first semester, review in January
Schedule
Units courses prerequisite and corequisite
Prerequisite or corequisite units are presented within each program
Learning unit contents
MODULE 1: Gaëtan Garraux - Functional neuroimaging in humans
1. THEORY - 12H (6x 2H)
Overview
Physiological bases of the recorded signals
PET imaging
BOLD/ASL fMRI imaging
Brain image processing
Brain image analyses
2. PRACTICE - 6H
Visit of the Cyclotron (Building B30)
PET/fMRI imaging data acquisition: 2h
PET/fMRI imaging data visualization/interpretation: 2h
Electrophysiology, EEG, Electromagnetic stimulation: 2h
MODULE 2 : Vincent Seutin & Dominique Engel - Neuron excitability properties
THEORY - 4H
Excitatory synaptic inputs in relation to Parkinson's disease - Dr Engel .
Physiology and pathophysiology of voltage-gated sodium channels - Pr Seutin.
PRACTICE - 6H - GIGA Neurosciences laboratory
2 X 3H (patch-clamp on cultured cells to evaluate mutated Na-channel propertie
MODULE 3: Laurence Delacroix & Rachelle Franzen - "Integrated "Journal Club
6 X 2H on the following thematics: Neuroimmunology - Neuroimaging - Neurophysiology and experimental models of neurodegenerative diseases
Learning outcomes of the learning unit
At the end of this course, the student will be able to:
-recognize and analyze brain imaging techniques (MRI, PET-Scan, etc.)
-explain the link between excitatory synaptic connections and Parkinson's pathology
-explain the physiology and pathophysiology of voltage-dependent sodium channels
-explain the principle of the "patch-clamp" technique and the practical protocol for its implementation.
-describe and criticize the role of neuroinflammation in diseases of the central nervous system
-present and critique a research article in cellular and molecular neurobiology, including notions of electrophysiology, imaging, and neuroinflammation.
Prerequisite knowledge and skills
Planned learning activities and teaching methods
- Ex-cathedra courses
- Practical courses in different laboratories (Cyclotron, GIGA neurosciences)
- Seminars: Research article readings + oral presentations of these articles by the students
Discussion and explanations with and by the professors.
Mode of delivery (face to face, distance learning, hybrid learning)
Recommended or required readings
Exam(s) in session
Any session
- In-person
oral exam
Other : Oral presentation of a research article (ppt) followed by a discussion
Additional information:
- Oral exam
- Principe: Research papers (in relation to the topics addressed during the courses) will be provided to all students at the beginning of the course (mid-September). One week before the exam, students will know which article they will have to present for the exam (short PPT - 5 min). The evaluation will assess the capacity of the students to analyze, understand and criticize the manuscript.
Work placement(s)
Organisational remarks and main changes to the course
Contacts
Pr Gaëtan GARRAUX
ggarraux@uliege.be
Dr Laurence DELACROIX
ldelacroix@uliege.be
Pr Vincent SEUTIN / Dr Dominique ENGEL
V.Seutin@uliege.be
Dominique.Engel@uliege.be
Dr Rachelle FRANZEN
rfranzen@uliege.be