2023-2024 / CHIM9314-1

Mass spectrometry technologies in biomedical research and their applications in the biotech industry

Duration

30h Th, 20h Pr, 10h AUTR

Number of credits

 Master in biomedicine (120 ECTS)5 crédits 

Lecturer

Marianne Fillet, Gabriel Mazzucchelli

Language(s) of instruction

English language

Organisation and examination

Teaching in the first semester, review in January

Schedule

Schedule online

Units courses prerequisite and corequisite

Prerequisite or corequisite units are presented within each program

Learning unit contents

Modern analytical methods requiring mass spectrometry for research purposes in the field of biomedical sciences but also for industrial purposes (biotechnology and pharmaceuticals) will be taught.
The following themes will be specifically addressed:
- at the technological level: latest technological advances in terms of mass spectrometry and upstream separation techniques; qualitative approaches vs quantitative approaches; microfluidic approaches; molecular imaging
 
- at the application level: proteomic and peptidomic analyzes; interactomics analyzes; metabolomics and fluxomics analyzes; molecular imaging; single cell analysis; pharma / biotech analyzes (QC, PKPD, tox); clinical / pre-clinical analyzes (biomarker monitoring)
 
Students will also have the opportunity to discuss these issues with experts and professionals in the field.

Learning outcomes of the learning unit

During this course, the techniques and approaches by mass spectrometry most commonly used in biomedical sciences will be taught. Students will learn to select the most suitable operating conditions depending on the application (biological issue and complexity of the sample to be analyzed).
A self-learning process will help the student to gain autonomy to analyze the problems that he might encounter during his professional career. Comparing his ideas with those of his peers and meeting with experts in the field will allow him to learn about collaboration and will aim to facilitate his integration into the professional environment.

Prerequisite knowledge and skills

NTA

Planned learning activities and teaching methods

The first contact with the teachers will be devoted to the presentation of the topics covered in this course (see section contents of the teaching unit).
Students will individually choose a theme according to their affinity. "Case studies" will then be offered to them by industrialists or researchers (concrete cases of analyzes to be carried out for biotechnology or pharmaceutical companies or in the context of fundamental or clinical research) (problem based learning). The teachers will mark out the written work to be returned with the student. The latter will also have to make an oral presentation to the whole group on the theme he has chosen. Teachers will complete as appropriate.
A visit to the laboratories and infrastructure will also be organized.

Mode of delivery (face to face, distance learning, hybrid learning)

Blended learning


Additional information:

Face-to-face activities alternating with remote activities will be set up. Practical details will be given during an information session at the start of the semester.

Recommended or required readings

NTA

Exam(s) in session

Any session

- In-person

oral exam

Written work / report


Additional information:

The evaluation of this teaching unit will include the marks obtained for the written work and the oral presentation in relation to the "case study" chosen by the student.

Work placement(s)

Organisational remarks and main changes to the course

 
Opening of the course with a minimum of 3 registrants

Contacts

Gabriel Mazzucchelli
 Institut de chimie B6c, quartier Agora
Allée du six août, 11
B4000 - Liege - BELGIUM
 Secretary Phone. : +32 (0) 4 366 34 33
Direct Phone. : +32 (0) 4 366 34 11
Fax. : +32 (0) 4 366 43 87
 E-Mail: Gabriel.mazzucchelli@uliege.be
 
Marianne Fillet
Labaoratoiry for the Analysis of Medicines
Marianne.fillet@uliege.be

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