Study Programmes 2016-2017
TOXI0441-1  
Experimental Toxicology
Duration :
10h Th
Number of credits :
Master in biomedicine (120 ECTS)2
Lecturer :
Corinne Charlier
Language(s) of instruction :
French language
Organisation and examination :
Teaching in the first semester, review in January
Units courses prerequisite and corequisite :
Prerequisite or corequisite units are presented within each program
Learning unit contents :
Use of in vivo and in vitro tests to evaluate toxicity of chemical substances and drugs
Learning outcomes of the learning unit :
To evaluate toxicity of chemical substances and drugs, and before human use, several experimental steps must be done :

  • micro-organism tests : speed and cheap, but with a lot of disadvantages (cell wall, none micro-oranite, specificity of ADN repair mechansisms, etc...);
  • eukaryotic cells tests : allow to control exactly the concentration used but not the study of influence of metabolic activation/inactivation (important in the study of cancer);
  • in vivo tests : results more sensitive and easier to transpose to human; the choice of a species is the "key" choice ; it is determinated by taking into account metabolic process and detoxification mechanisms.
Prerequisite knowledge and skills :
Having had success in "Toxicological precepts" of the former academic year
Planned learning activities and teaching methods :
Not appliable
Mode of delivery (face-to-face ; distance-learning) :
...
Recommended or required readings :
...
Assessment methods and criteria :
Oral evaluation in january
Work placement(s) :
Organizational remarks :
Contacts :
Professeur Corinne CHARLIER

Clinical,Forensic and Environmental Toxicological laboratory

CHU B35

Sart-Tilman, B4000 Liège

Tél.04/3667683

Fax 04/3668889

e-mail : C.Charlier@chu.ulg.ac.be