BIOC0724-1 : Chemistry of biological macromolecules

Study Programmes 2016-2017

WARNING : 2015-2016 version of the course specifications

BIOC0724-1

Chemistry of biological macromolecules

Duration :

20h Th

Number of credits :

Specialised master in nanotechnology		2

Lecturer :

Moreno Galleni, André Matagne

Coordinator :

Moreno Galleni

Language(s) of instruction :

French language

Organisation and examination :

Teaching in the second semester

Units courses prerequisite and corequisite :

Prerequisite or corequisite units are presented within each program

Learning unit contents :

Editer

1) Chemical properties of amino acids and of the polypeptide chain
1.1 Nature of the polypeptide chain
1.2 Amino acids
1.3 Detection of aminoacids, peptides and proteins
1.4 Determination of the protein size
1.5 Determination of the aminoacid sequence
1.6 Chemical synthesis of peptides
1.7 Non ribosomal synthesis of peptides
1.8 Post transcription modification of the polypeptide chain
2) Mechanism of protein localization in prokaryotes and eukaryotes
3) Interactions affecting the properties of proteins
3.1 Nature of non covalent interactions
3.2 Intramolecular interactions
4) Conformational properties of proteins
4.1 Secondary and ternary structures of proteins
4.2 Spectroscopic properties od proteins in solution
5) Biophysical properties of soluble and membranar properties

Learning outcomes of the learning unit :

The course will be devoted to the structural and chemical properties of proteins.

Prerequisite knowledge and skills :

Lectures in general biochemistry
Thermodynamic and classical physic
Organic chemistry

Planned learning activities and teaching methods :

The practical course (20 hours) will be devoted to the production and chaacterisation of a zinc beta-lactamase.

Mode of delivery (face-to-face ; distance-learning) :

10 lessons of 2 hours